Effects of Remote Ischemic Preconditioning on Renal Outcomes Following Lower Limb Revascularization
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- AKI
研究概览
简要总结
The aim of this study is to evaluate the role of remote ischemic preconditioning (RIPC) in preventing acute kidney injury after lower limb revascularization.
Remote ischemic preconditioning(RIPC) is a simple, cost-free and non invasive procedure (transient upper limb ischemia/reperfusion) that could provide organ protection (Heart, Brain and Kidney) following ischemia injuries.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Care Provider, Investigator, Outcomes Assessor)
盲法说明
The RIPC procedure were performed in the ward before going to operating room, and this is blinded to Investigators and surgical case anesthesiologist
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for open limb revascularization
排除标准
- •Peripheral vascular disease affecting upper limbs
- •Chronic kidney disease in stage 4 or 5 (eGFR<30 ml/min/1,73m2)
- •Patients underwent contrast-enhanced radiological exams in the previous 7 days
- •Treatment with glibencamide or prostaglandins
结局指标
主要结局
AKI
时间窗: 72 Hours
the incidence of Acute Kidney Injury, defined as absolute rise of ≥ 0.3 mg/dL and/or a relative increase of 25% in serum creatinine compared to preoperative
次要结局
- AKI Risk Score(24 Hours)
研究者
Alberto Noto
Professor of Anaesthesia
University of Messina