Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers: a Two-arm, Double-blind, Placebo-controlled, Randomized Controlled Trial.
试验速览
- 阶段
- 2 期
- 状态
- 进行中（未招募）
- 入组人数
- 80
- 试验地点
- 9
- 主要终点
- Time to complete wound closure
研究概览
简要总结
The safety and efficacy of beta glucan products, and specifically TR 987, in the treatment of chronic venous insufficiency ulcers has been established. This study is designed to determine the most efficient method of treatment.
详细描述
This is a multi-center, randomized, double-blind, placebo-controlled study to evaluate the effectiveness of TR 987 gel. It is a two-arm, design: One group will receive twice-weekly applications of 0.1% TR 987 in a gel base plus SoC for the first 4 weeks. The other group will receive twice-weekly applications of placebo gel base plus SoC for the same period of time. After 4 weeks, both groups will receive once weekly applications of their assigned treatment for the remaining 8 weeks of the trial. The Standard of Care therapy in this study is multi-layer compression therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subject is at least 18 years old
- •Female subjects are not pregnant or breastfeeding.
- •Study ulcer has been present for at least one month and has undergone more than 2 weeks, but less than 12 months of continuous high-strength compression with less than 40% healing.
- •Study ulcer is a minimum of 2.0 cm2 and a maximum of 20.0 cm2, extending through the full thickness of the skin, but not down to muscle, tendon, or bone at the randomization visit.
- •Study ulcer has a clean, granulating base with minimal adherent slough at the randomization visit.
- •If more than one ulcer is present on the same leg, they must be more than 2 cm apart and only the larger ulcer will be included in the study.
- •Adequate arterial flow, as measured by an Ankle Brachial Pressure Index (ABI) of greater than 0.
- •(Calculations will be made using measurements from both posterior tibial and dorsalis pedis arteries, as well as both arms) and/or Skin Perfusion Pressure (SPP) >
- •Subject understands and is willing to participate in the clinical study and can comply with weekly visits and the follow-up regimen.
- •Patient understands and is willing to participate in the clinical study and can comply with weekly visits and the follow-up regimen.
- •Patient has read and signed the IRB/IEC approved Informed Consent Form before screening procedures are undertaken.
排除标准
- •Study ulcer deemed by the Investigator to be caused by a medical condition other than venous insufficiency.
- •Study ulcer exhibits clinical signs and symptoms of infection.
- •Study ulcer requires enzymatic debridement during the study.
- •Study ulcer has undergone 12 or more months of continuous high-strength compression therapy over its duration.
- •Study ulcer is less than 2.0 cm2 or greater than 20.0 cm
- •Study ulcer extends more than 50% below the malleolus.
- •Study ulcer is treated with a topical antibiotic during the screening phase.
- •Study ulcer has been treated with tissue engineered material (e.g., Apligraf® or Dermagraft®) or other scaffold materials (e.g., Oasis or Matristem) within 30 days prior to the TV1 Randomization visit.
- •Study ulcer requiring negative pressure wound therapy or hyperbaric oxygen during the course of the trial.
- •History of radiation at the study ulcer site.
- •Study ulcer decreases in area by 30% or more during the 14 days screening period.
- •Subjects who are unable to understand the aims and objectives of the trial or has a known history of poor adherence with medical treatment.
- •Presence of any condition(s) that seriously compromises the subject's ability to complete this study.
- •All females of childbearing potential who are not using a highly effective method of birth control (failure rate less than 1% per year), such implants, injectables, combined oral contraceptives, some IUDs, sexual abstinence or vasectomized partner.
研究组 & 干预措施
TR987
This group will receive twice-weekly applications of 0.1% TR 987 in a gel base plus SoC for the first 4 weeks, then once weekly applications for the remaining 8 weeks of the trial.
干预措施: 0.1% TR 987 (Drug)
Placebo
This group will receive twice-weekly applications of placebo gel base plus SoC for the first 4 weeks, then once weekly applications for the remaining 8 weeks of the trial.
干预措施: Placebo gel (Drug)
结局指标
主要结局
Time to complete wound closure
时间窗: 12 weeks
次要结局
- Percentage of subjects with complete ulcer healing(12 weeks)
- Change in ulcer size(12 weeks)
- Incidence of adverse events(12 weeks)