ACTRN12614001219673已完成未知
Multiparametric MRI as a Predictor of Tumour Response in Patients with Anal Canal Cancer Managed with Chemoradiotherapy
Dr Michael Jones0 个研究点目标入组 20 人开始时间: 2014年11月19日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •1.Patient capable of providing informed consent
- •2.Patient deemed suitable for protocol treatment as
- •assessed by Radiation and Medical Oncologists
- •3.Histological diagnosis of invasive primary squamous
- •cell carcinoma of the anal canal
- •4.TNM Stage: T2-4, N0-3 based on the
- •following diagnostic workup
- •a.History & physical examination
- •b.Digital Rectal Exam (DRE) stating primary size and
- •distance from anal verge
- •c.Groin examination with documentation of any
- •lymphadenopathy (location: right vs. left; medial vs.
- •lateral; mobile vs. fixed; and size)
- •d.Clinically positive nodes
- •i .Small inguinal nodes < 1cm in size felt to be clinically
- •positive must be confirmed via biopsy
- •ii. A biopsy is not needed for enlarged inguinal,
- •perirectal or pelvic nodes on examination or imaging
- •if >1cm and considered to be clinically positive
- •e.Anal biopsy
- •f.CT abdomen and pelvis
排除标准
- •1.ECOG performance status >2
- •2.Significant comorbidities that would interfere with
- •the completion of treatment
- •3.Renal insufficiency (Creatinine > 150)
- •4.Prior radiotherapy to the pelvis that would overlap in
- •the treatment fields
- •5.Prior surgery for cancer of the anus that removed all
- •macroscopic cancer
- •6.Prior systemic chemotherapy for anal cancer
- •7.Evidence of distant metastases (M1) if this precludes
- •radical pelvic treatment
- •8.Women who are pregnant or lactating
- •9.Inability to have a MRI due to:
- •a.Implanted magnetic metal e.g. intraocular metal
- •b.Pacemaker / Implantable defibrillator
- •c.Extreme claustrophobia
研究者
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