Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Identification of Secreted Markers for Tumor Hypoxia through tissue collection
研究概览
简要总结
The purpose of this study is to identify and confirm new blood and tissue markers for prognosis and tumor hypoxia. Tumor hypoxia, or the condition of low oxygen in the tumor, has been shown to increase the risk of tumor spread and enhance tumor resistance to the standard treatment of radiation and chemotherapy in head and neck and lung cancers. We have recently identified several proteins or markers in the blood and in tumors (including osteopontin, lysyl oxidase, macrophage inhibiting factor and proteomic technology) in the laboratory that may be able to identify tumors with low oxygen levels or more aggressive behaving tumors.
详细描述
The endpoints of the study are
- To validate the prognostic significance of OPN in H&N and lung cancer patients and to monitor its level during active therapy and follow up for cancer surveillance.
- To identify a gene and protein signature for hypoxia in H&N and lung cancer patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically confirmed squamous cell carcinoma of the head and neck sites or non-small cell lung cancer, or relatives of patients with histologically confirmed squamous cell carcinoma of the head and neck.
- •Able to sign a Stanford IRB approved consent form
排除标准
- •Refuse or unable to sign an IRB approved consent form.
- •Refuse to be contacted in the future for follow up.
结局指标
主要结局
Identification of Secreted Markers for Tumor Hypoxia through tissue collection
时间窗: before therapy, weekly during therapy
次要结局
未报告次要终点