The Accuracy of Fecal Calprotectin in Detecting Esophageal Varices in Egyptian Patients With Liver Cirrhosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 156
- 试验地点
- 1
- 主要终点
- measuring fecal calprotectin level (microgram/gram) for predicting esophageal varices
研究概览
简要总结
The goal of this cross-sectional observational study is to evaluate the accuracy of fecal calprotectin versus non-invasive scores in assessing the presence and grading of esophageal varices in Egyptian patients.
Researchers will compare fecal calprotectin levels in cirrhotic patients with and without esophageal varices (EVs) and healthy subjects. researchers will also evaluate the performance of fecal calprotectin, AST to platelet ratio index (APRI) score, fibrosis-4 (FIB-4) score, albumin-bilirubin (ALBI) score, platelet-albumin-bilirubin (PALBI) score, and platelet-spleen diameter ratio (PSR) for predicting esophageal varices.
Participants will undergo history-taking, clinical examination, laboratory investigations, fecal calprotectin, abdominal ultrasonography, and upper endoscopy. Endoscopic grading of esophageal varices will be done using Paquet's classification. The APRI, FIB-4, ALBI, PALBI, and PSR scores will be calculated. The performance of fecal calprotectin for predicting EVs will be compared versus other non-invasive scores.
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥18 years
- •Liver cirrhosis
排除标准
- •Patients aged < 18 years.
- •Inflammatory bowel disease.
- •Infectious gastroenteritis.
- •Malignancy.
- •Patients on proton pump inhibitors or NSAID.
- •Patients with spontaneous bacterial peritonitis.
- •Patients with hepatic encephalopathy.
- •Unwilling to participate in our study.
结局指标
主要结局
measuring fecal calprotectin level (microgram/gram) for predicting esophageal varices
时间窗: through study completion, an average of 1 year
次要结局
- comparing fecal calprotectin versus non-invasive scores for predicting esophageal varices(through study completion, an average of 1 year)
研究者
Rania Mamdouh Elkafoury
Lecturer of Tropical Medicine
Tanta University