Efficacy of Lodhradi Facepack in Acne Vulgaris(Mukhadushika)
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Reduction in GAGS Score
研究概览
简要总结
Acne vulgaris is a chronic, inflammatory skin disease of the pilosebaceous unit, with open or closed comedones, papules, pustules, or nodules on the face or trunk, result in pain, erythema, hyperpigmentation, or scars. 9.4% of the global population has acne and 85% of them are teenagers. Treatments as per American Dermatological association guidelines include topical therapies, systemic antibiotics, hormonal agents, oral isotretinoin, physical modalities, complementary and alternative medicine, and dietary and environmental interventions. Though topical antibiotic therapies are the mainstay of grade II acne; adverse effects like irritant dermatitis, bacterial resistance are big concerns. Herbal medicines are becoming a promising strategy in cosmetics and skin care products and researches showed effectiveness of herbal and Ayurveda formulations in moderate acne vulgaris (Mukhadushika) with fewer adverse events. Mukhadushika charecterised by Salmali-kantakaakara pidaka [lesions resembling the prickles of silk cotton tree] , yoonam vakre [occurs in the face of young people] sarujam (associated with pain),Ghana:[thick and dense lesion],medogarbha: [presence of fatty pultaceous material inside the lesion] The drugs having varnya(enhancing complexion), kushtaghna(curing skin diseases), kandoogna(antipruritic) and krimigna(Antihelminthic) actions are utilized in Ayurveda treatment. Lodhradi Facepack (LF) is a novel medicine formulated with bark of Lodhra (Symplocos cochinchinensis.Lour.), root of Manjishta (Rubia cordifolia L.), rhizhome of Yashtimadhu (Glycyrrhiza glabra L.) and Multani-mitti (Fullers earth); which are having Mukhadushikahara, Varnya and Kandugna properties. Also unlike antibiotics ,herbal medications have no side effects like irritant dermatitis, bacterial resistance etc . Present medication if proved to be effective can be used independently in moderate Acne vulgaris and adjuvant in severe acne along with other medications.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 35.00 Year(s)(—)
- 性别
- All
入选标准
- •Participants with Global Acne Grading Score (GAGS) between 19-30 of age group 18-35yrs.
排除标准
- •Pregnant or Lactating women Patients under other medications for Acne vulgaris.
结局指标
主要结局
Reduction in GAGS Score
时间窗: 0th day | 56th day
次要结局
- for standardisation of study drug physical parameters like ash value ,extractive value,TLC(Before starting study)
研究者
Sumy Basheer
Government Ayurveda college, Thiruvananthapuram
