A study of leaky gut syndrome in dengue infection

Department of Clinical Tropical Medicine0 个研究点目标入组 40 人开始时间: 2021年2月8日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•1. Participants diagnosed with dengue (by dengue antigen NS1 or PCR for dengue virus) with or without warning signs, fulfilling World Health Organization criteria and in-patient treatment, 2. No previous diagnosed dengue fever (by taking history), 3. Age 18-50 years old, 4. Normal consciousness without significant fatigue or dehydration, 5. No known any medical illness, no current medication taking (except acetaminophen will be allowed in patients with dengue infection group only), 6. Able to provide written informed consent.

•1. Diagnosis of severe dengue infection, fulfilling World Health Organization criteria. Severe dengue infection is a potentially fatal complication, due to severe plasma leaking, severe fluid accumulation, respiratory distress, severe bleeding, or organ impairment, 2. Presence of comorbidities (e.g. pneumonia, diarrhea, diabetes, other local or systemic infections, cardiovascular or cerebrovascular or renovascular comorbidities, etc.) at time of admission, 3. Recent use of medication (except acetaminophen will be allowed in patients with dengue infection group only) or over the counter medication, prebiotic, probiotic or vitamin supplements, 4. History of gastrointestinal surgery, 5. Family history of inflammatory/irritable bowel syndrome, 6. Known to hypersensitivity reaction to mannitol and/or lactulose, 7. Presence of alcohol intake or substance misuse, 8. Pregnancy, 9. During menstruation period, 10. Non-Thai speaking participants.

发起方

Department of Clinical Tropical Medicine