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临床试验/NCT06608667
NCT06608667已完成不适用

The Evaluation of Ischemia-reperfusion Injury in the Donor Liver Can Be Achieved Through the Utilization of Noninvasive Near-infrared Hyperspectral Imaging.

First Affiliated Hospital Xi'an Jiaotong University1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2022年6月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
40
试验地点
1
主要终点
Hyperspectral imaging to assess ischemia-reperfusion injury in liver grafts

研究概览

简要总结

Based on hyperspectral imaging equipment, this project collected hyperspectral imaging data of donor livers, analyzed various parameters, investigated the detection capability of hyperspectral imaging for assessing donor liver quality, gathered patient prognosis information, examined the correlation between early postoperative complications and hyperspectral imaging data, and explored characteristic parameters for evaluating donor liver quality using hyperspectral imaging technology. The occurrence of early complications was predicted.

详细描述

Hyperspectral imaging (HSI) is an advanced optical technology that combines spectroscopy and imaging, providing a non-destructive approach for clinical diagnosis. In recent years, hyperspectral imaging has emerged as a prominent research topic in the field of applied medicine. Liver transplantation is considered the most effective treatment for end-stage liver disease; however, the scarcity of donor livers and the growing number of patients awaiting transplantation pose significant challenges to global organ transplantation. The evaluation of donor livers has always been a focal point in liver transplantation. Currently, clinical evaluation relies heavily on subjective judgment by transplant physicians based on general appearance and touch assessments, along with clinical examinations and pathological biopsy results. Nevertheless, studies have demonstrated that these methods are not entirely reliable for assessing liver quality. Therefore, it is crucial to identify additional evaluation parameters and establish a convenient, reliable, and non-invasive method to assess donor liver quality. This study aims to analyze hyperspectral imaging data alongside clinical test data and recipient complications occurring between June 2022 to June 2024 to evaluate the quality of donor livers using hyperspectral imaging technology while exploring potential evaluation parameters.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Recipients ranged in age from 18 to 65
  • Donor age ≥ 18 years

排除标准

  • Recipients are younger than 18 years or older than 65 years
  • Donor younger than 18 years
  • Secondary liver transplantation.
  • Multiple organ transplantation.

结局指标

主要结局

Hyperspectral imaging to assess ischemia-reperfusion injury in liver grafts

时间窗: From June 1,2022 to June 30,2024

Assessment of severity of ischemia-reperfusion injury of donor liver grafts by hyperspectral imaging

次要结局

  • Assessment of fatty liver graft using hyperspectral imaging(From June 1,2022 to June 30,2024)
  • Hyperspectral imaging predicts early serologic markers of liver function and inflammatory factors(From June 1,2022 to June 30,2024)
  • Assessing early allograft dysfunction after liver transplantation using hyperspectral imaging(From June 1,2022 to June 30,2024)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Hu Liangshuo

Principal Investigator

First Affiliated Hospital Xi'an Jiaotong University

研究点 (1)

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