The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions As an Opioid Free Anaesthesia on Surgical Field in Patients Undergoing Nasal Surgeries. a Randomized Controlled Trial
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- surgical field using the average category scale (ACS).
研究概览
简要总结
Nasal surgeries are common day case procedures. Although surgical complications are rare, bleeding decreases surgical field visibility and may cause vascular, orbital or intracranial complications in addition to failure of procedure. So, it is crucial to maintain hypotensive anaesthesia to optimize the surgical field.
详细描述
In this study the investigators compare the effect of; propofol- lidocaine-magnesium and ketamine- lidocaine- magnesium infusions to dexmedetomidine- lidocaine- magnesium infusion on surgical field quality, intraoperative haemodynamics, surgical time, recovery time, sedation score, time to first rescue analgesic and incidence of PONV in patients undergoing nasal surgeries
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA I-II,
- •scheduled for elective nasal surgery
排除标准
- •Patients with uncontrolled hypertension.
- •Patients with cardiac disease.
- •Patients with renal, hepatic or cerebral insufficiency.
- •Patients with coagulopathy or receiving drugs influencing blood coagulation.
- •Anaemia, haemoglobinopathies or polycythemia.
- •Pregnancy.
- •Patients with known sensitivity to any of the study drug.
研究组 & 干预措施
Group PLM (propofol-lidocaine-magnesium)
intravenous infusion of propofol, lidocaine and magnesium sulfate.
干预措施: Intravenous Infusion of propofol, lidocaine, Magnesium sulfate (Drug)
Group KLM (ketamine-lidocaine-magnesium)
intravenous infusion of Ketamine, lidocaine and magnesium sulfate
干预措施: Intravenous infusion of ketamine, lidocaine, Magnesium sulfate (Drug)
Group DLM (Dexmeditomidine-lidocaine-magnesium)
Intravenous infusion of Dexmeditomidine, lidocaine and magnesium sulfate
干预措施: Intravenous infusion of dexmedetomidine, lidocaine, Magnesium sulfate (Drug)
结局指标
主要结局
surgical field using the average category scale (ACS).
时间窗: During the operation
Degree of surgical field bleeding
次要结局
- sedation using Ramsy sedation score(First hour postoperative)
研究者
Rania Maher Hussien, MD
Associate Professor
Ain Shams University