NCT02164942终止不适用
LCI-GU-BLA-SPEC-001: Expression of the Aurora Kinase Family and Chemoresistance in Muscle-Invasive Bladder Cancer
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Correlation of pathologic response rate and aurora kinase expression
研究概览
简要总结
This is a prospective, single arm, observational study examining aurora kinases and circulating tumor cells in subjects with bladder cancer being treated with standard cisplatin-based chemotherapy.
详细描述
Subjects will receive neoadjuvant cisplatin-based chemotherapy followed by radical cystectomy per standard of care. CTC and Aurora kinase expression patterns will be analyzed in subject specimens for correlation with clinicopathologic outcome. Subjects will be on study for a total of five years following cystectomy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Correlation of pathologic response rate and aurora kinase expression
时间窗: Within 6 months of subject enrollment
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
进行中（未招募）
1 期
A Study of LY3295668 Erbumine in Participants With Relapsed/?Refractory NeuroblastomaCTIS2024-512102-25-00Eli Lilly & Co.1
已完成
1 期
Alisertib for Acute Myeloid LeukemiaAcute Myelogenous LeukemiaNCT01779843Massachusetts General Hospital22
终止
1 期
VIC-1911 Monotherapy in Combination With Sotorasib for the Treatment of KRAS G12C-Mutant Non-Small Cell Lung CancerNon-small Cell Lung CancerNCT05374538Vitrac Therapeutics, LLC3
已完成
1 期
Phase I Study of MLN8237 and Pazopanib in Patients With Solid TumorsMalignant Neoplasm of BreastCNS MalignancyMalignant Neoplasm of Gastrointestinal TractGenitourinary Neoplasms Malignancy and Gender UnspecifiedHead and Neck NeoplasmsMalignant Neoplasm of ThoraxMelanomaNCT01639911University of Illinois at Chicago28
已完成
2 期
MLN8237 for Treatment of Participants With Ovarian, Fallopian Tube, or Peritoneal CarcinomaOvarian CarcinomaNCT00853307Millennium Pharmaceuticals, Inc.31