Incidence, Risk Factors and Consequences of Acute Kidney Injury in Patients Undergoing Esophageal Cancer Surgery: a Historical Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 254
- 试验地点
- 1
- 主要终点
- Incidence of postoperative acute kidney injury
研究概览
简要总结
Esophagectomy serves as an exemplar of major operative trauma, with well-known risk of pulmonary, cardiac, anastomotic, and septic complications and the presence of postoperative complications after esophagectomies for cancer is associated with a reduced long-term survival. There is a paucity in the literature regarding postoperative renal outcomes after esophageal surgery, with a wide range of incidence.
The investigators will conduct a historical cohort study aiming to evaluate the incidence of postoperative acute kidney injury in patients undergoing elective esophageal cancer surgery. Secondary, the investigators will assess the progression of the acute injury and the association with adverse pulmonary, cardiac, anastomotic, and septic events, as well as increase in hospital stay and mortality. The investigators will also identify risk factors associated with acute kidney injury occurrence.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective esophagectomy
排除标准
- •End-stage renal disease
- •Missing data for acute kidney injury definition
- •Second surgery (for patients having multiple surgeries performed during a 30-day period, only the first in each period will be included)
结局指标
主要结局
Incidence of postoperative acute kidney injury
时间窗: within 48 hours after surgery
according to KDIGO criteria
次要结局
- Incidence of sepsis(within 30 days after surgery)
- Incidence of transient or persistent postoperative acute kidney injury(48 hours after development of acute kidney injury)
- Number of patients with renal recovery(at 7 days, after 30 days and 3 months)
- Incidence of postoperative pulmonary complications(within 30 days after surgery)
- Increase in length of hospital stay(1 year)
- Incidence of major adverse cardiac and cerebrovascular events (MACCE)(within 30 days after surgery)
- Mortality in hospital(1 year)
研究者
Ilaria Godi
Principal Investigator
Azienda Ospedaliera di Padova