NCT00148382已完成1 期
Randomized, Double Blind, Parallel Group, Repeat Dose Pharmacokinetic and Pharmacodynamic Study of Four Doses of ATL-962 (40mg, 80mg, 120mg 240mg) in Otherwise-Healthy Obese Volunteers
Alizyme1 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2005年4月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Pharmacokinetics of metabolites of ATL-962
研究概览
简要总结
The purpose of this study is to investigate the amount of metabolites of ATL-962 in the blood and to investigate the effect of ATL-962 on the amount of fat that is excreted in the faeces in subjects who are obese
详细描述
Obesity is a significant and increasing clinical problem. There is a need for effective therapeutic agents to help people reduce weight. ATL-962 is a lipase inhibitor which could reduce the amount of fat absorbed from a person's diet, leading to weight reduction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Obese, otherwise-healthy subjects
- •Body mass index 30-45kg/m2
排除标准
- •Women who are pregnant or breast feeding
- •Any drug treatment within 2 weeks of commencement of dosing in this study
结局指标
主要结局
Pharmacokinetics of metabolites of ATL-962
次要结局
- Effect of ATL-962 on faecal fat excretion
- Safety and tolerability of ATL-962
研究者
研究点 (1)
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