Tissue Inhibitor of Metalloproteinases 2 Level Predicts Acute Kidney Injury in Patients Undergoing Cardiac Surgery
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- the development of CSA-AKI
研究概览
简要总结
Acute kidney injury (AKI) is one of the most frequent major complications in patients undergoing cardiac surgery. CSA-AKI is independently related to increased perioperative mortality, increased hospital and ICU length of stay as well as heath care expenditure. Identification of relevant biomarkers may lead to early diagnosis and improve patient outcomes and health care costs. The pathophysiology of CSA-AKI is complex and ischemia-reperfusion injury is one of the important factors. Recently, it has been shown that Tissue Inhibitor of Metalloproteinases 2 (TIMP2) is associated with ischemia-reperfusion injury. In this study, relationship between TIMP2 with the risk of CSA-AKI was analyzed and the predictive value of elevated level of TIMP2 for early prediction of CSA-AKI was further evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients (≥18 years old) underwent on-pump cardiac surgery
- •admitted to ICU immediately after surgery
排除标准
- •Patients younger than 18 years
- •with prior AKI
- •end-stage kidney disease
- •need for chronic hemodialysis
- •pregnant patients
- •unable to give written consent for participation
研究组 & 干预措施
TIMP2 Tertile 1
Other: TIMP2 level
干预措施: TIMP2 level (Drug)
TIMP2 Tertile 2
Other: TIMP2 level
干预措施: TIMP2 level (Drug)
TIMP2 Tertile 3
Other: TIMP2 level
干预措施: TIMP2 level (Drug)
结局指标
主要结局
the development of CSA-AKI
时间窗: 1 Week
the development of CSA-AKI
次要结局
- AKI severity(1 Week)
- need for RRT(1 Week)
- duration of AKI (≥7 days)(1 Week)
- length of ICU stay(up to 28 days)
- post-operative hospital stay(up to 28 days)
研究者
Jiahao Zhang
Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University
Zhongnan Hospital