NCT02225483已完成不适用
Phenotypic Heterogeneity in Hemophilia A: An Investigation of the Role of Platelet Function
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 2
- 主要终点
- Procoagulant platelet-derived microparticle formation
研究概览
简要总结
The is study will examine whether variation in clinical bleeding frequency and severity among boys with severe Hemophilia A (Factor VIII deficiency) is associated with variations in laboratory measurements of platelet activity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Years 至 20 Years（Child, Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •documented circulating FVIII level of ≤1%
- •age 3 - 20 years
- •may be on primary or secondary prophylaxis
- •granting of informed consent
排除标准
- •measurable inhibitor level at the time of enrollment
- •ingestion of aspirin/supplement known to influence platelet function within 14 days of blood sampling, or ibuprofen within 3 days
结局指标
主要结局
Procoagulant platelet-derived microparticle formation
时间窗: At time of enrollment
Platelet aggregation
时间窗: At time of enrollment
Whole blood platelet aggregation responses
次要结局
未报告次要终点
研究者
研究点 (2)
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