Effects of Lifestyle and Physical Fitness on Cardiovascular Health: a Cohort Study in Chinese Occupational Population
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 18,512
- 试验地点
- 1
- 主要终点
- the composite end point of new major adverse cardiovascular events
研究概览
简要总结
The incidence and prevalence of metabolic risk factors such as obesity, hypertension, diabetes, and dyslipidemia, as well as cardiovascular diseases (CVD), are continuously rising among the occupational population in China, primarily comprising the middle-aged and young adults. Unhealthy lifestyles and declining physical fitness are independent risk factors affecting cardiovascular health. Additionally, the level of physical fitness is influenced by postnatal lifestyles. Lifestyle factors related to cardiovascular health in the occupational population encompass various aspects, including smoking, physical activity, diet, sleep, psychological stress, etc. These factors may interact or have a synergistic effect, necessitating a comprehensive assessment.
This project proposes a prospective cohort study design to establish a monitoring cohort for lifestyle and physical fitness among the occupational population. The study will track and follow individuals with or without any CVD metabolic risk factors, collecting information on general status, lifestyle, physical fitness, and health examination data. Exposure factors such as lifestyle and physical fitness will be measured annually, and the occurrence of CVD-related health outcomes will be observed. The aim is to develop a comprehensive evaluation index for cardiovascular health lifestyle, analyze the direct and indirect impacts of lifestyle and physical fitness on the occurrence and development of CVD, and explore potential mediating and moderating effects of physical fitness in the association between lifestyle and cardiovascular health.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 59 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •adults between 18-59 years of age
- •occupational staff
- •willing to accept long-term follow-up
排除标准
- •participants with previous CVD history such as myocardial infarction, stroke and severe aortic stenosis;
- •with cancer;
- •with congenital genetic diseases, or cannot cooperate with the investigation and follow-up due to acquired diseases, such as congenital heart disease, paralysis, deafness, dementia, mental abnormality, developmental retardation, etc.;
- •with exercise contraindications;
- •duration of pregnancy;
- •refuse to sign the informed consent.
结局指标
主要结局
the composite end point of new major adverse cardiovascular events
时间窗: 10 years
including cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization and unstable angina pectoris requiring hospitalization
次要结局
- level of diastolic pressure(10 years)
- new incidence of each major adverse cardiovascular events(10 years)
- new incidence of cancer(10 years)
- level of systolic pressure(10 years)
- new incidence of all-cause death(10 years)
- level of blood lipid(10 years)
- level of BMI(10 years)
- level of metabolic equivalents (METs)(10 years)
- level of maximal oxygen uptake (VO2max)(10 years)