Improvement of Hypodopaminergic Syndrome With Dopaminergic Treatment in Early Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 4
- 主要终点
- Evolution of apathy in Parkinson's disease
研究概览
简要总结
The objective of this study is to describe the evolution of hypodopaminergic syndrome in patients with Parkinson's disease.
详细描述
All patients to be included have been clinically described in the early phase of their disease, before instauration of dopaminergic treatment, in the context of a former study ("Non Motor Aspects in De Novo Parkinson's Disease (Honeymoon) NCT02786667") between june 2012 and june 2016.
3 to 5 years after this study, those patients who started dopaminergic treatment will be evaluated again.
The objective of this study, which takes place 3 to 5 year after the initial evaluation, is to measure the evolution of apathy and other symptoms of the hypodopaminergic syndrome.
Secondary objectives are the evolution of other parameters including pain, personality and behavior. All parameters measured have been determined of each patient in the Honeymoon study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 33 Years 至 72 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who participated in "Non Motors Aspects in De Novo Parkinson's Disease (Honeymoon)" NCT02786667
- •Patients under dopaminergic treatment, with stable dopaminergic treatment for at least 2 months
- •Patients with medical insurance
- •signed informed consent
排除标准
- •diagnosis other than Parkinson's Disease
- •dementia (Mattis <130)
- •patients protected by law (i.e. pregnant or parturient women)
结局指标
主要结局
Evolution of apathy in Parkinson's disease
时间窗: 1day
Evolution of apathy in Patients with Parkinson's disease under dopaminergic treatment. The degree of apathy is evaluated with the "Starkstein Scale of Apathy".
次要结局
- Evolution of quality of life in Parkinson's disease(1 day)
- Evolution of eating behavior in Parkinson's disease(1 day)
- Evolution of impulsivity in Parkinson's disease(1 day)
- Evolution of personality in Parkinson's disease(1 day)
- Evolution of somnolence in Parkinson's disease(1 day)
- Evolution of hypodopaminergia in Parkinson's disease(1 day)
- Apparition of hyperdopaminergic symptoms in Parkinson's disease(1 day)
- Evolution of pain in Parkinson's disease(1 day)