Impact of CO2 on Cerebral Blood Flow in Infants Less Than 6 Months During General Anaesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- NIRS variation
研究概览
简要总结
The study aims at assessing cerebral blood flow variations following expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia.
详细描述
The study aims at assessing cerebral blood flow (measured with Near-Infrared Reflectance Spectroscopy - NIRS - and transcranial Doppler - DTC) variations following end-tidal expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia performed according to standards of care.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
盲法说明
Patient is under general anesthesia
入排标准
- 年龄范围
- — 至 6 Months（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age < or = 6 months
- •ASA class < or = 3
- •General anesthesia required for surgery
排除标准
- •No parental consent
- •Emergency surgery
- •Preexisting neurological condition
- •Hemodynamic instability
- •Preexisting hypoxemia and/or hypercapnia
- •Laparoscopy or thoracoscopy, if expected EtCO2 level achieving would require unsafe ventilation parameters
研究组 & 干预措施
Main Arm
In each patient, under ongoing standard general anesthesia in a stable state, EtCO2 is manually modified to reach predefined values, and after waiting until cerebral blood flow has reached steady state, NIRS and DTC values are noted.
干预措施: EtCO2 modification (Procedure)
结局指标
主要结局
NIRS variation
时间窗: 5 to 10 minutes
Near-Infrared Spectroscopy value variation after EtCO2 modification
次要结局
- DTC variation(5 to 10 minutes)
研究者
Bruno Greff
Principal Investigator
St. Justine's Hospital