Cervical Rippening With Antiprogesterone in Midtrimester Abortions
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 145
- 试验地点
- 1
- 主要终点
- success of abortion induction
研究概览
简要总结
Induction of midtrimester abortion includes cervical ripening and then contraction to induce uterine evacuation. There are several protocols, but most of them include using prostaglandins (PG). The disadvantages of using PG include uncomfortable side effects and limits of using it for women after cesarean section. Mifepristone is an antiprogesterone drug and been used for induction of abortion in first and second trimesters abortions. The aim of this study is to explore the effectiveness of Mifepristone for cervical ripening before high dose Oxytocin drip.
详细描述
The aim of this study is to explore the effectiveness of Mifepristone for cervical ripening before high dose Oxytocin drip in midtrimester abortions. After informed consent, all the women will be randomized for Mifepristone or placebo. 48 hours later, high dose oxytocin drip will be started and we will examine the success rate to induce abortion, the duration from starting oxytocin till evacuation of uterus and side effects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •midtrimester late abortion
- •midtrimester induced abortion
排除标准
- •placenta previa
- •infected abortion
- •rupture of membranes
- •s/p cesarean section *2 or more
研究组 & 干预措施
Pitocin
Treatment with Pitocin after mifegine
干预措施: Mifepristone (Drug)
Cytotec
Treatment with cytotec after mifegine
干预措施: Mifepristone (Drug)
结局指标
主要结局
success of abortion induction
abortion induction duration
次要结局
未报告次要终点