Study " COFLORES ":Imaging of Coronary Reserve Without Tracers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 53
- 试验地点
- 1
- 主要终点
- Myocardial perfusion
研究概览
简要总结
Myocardial perfusion is a major parameter characterizing the status of capillary circulation of the myocardium. Its quantification is possible using Magnetic Resonance Imaging (MRI) during the 1st pass of a contrast agent through the capillary system. This technique is radiation-free, but it is difficult to repeat measurements during a single exam. Also, a number of patients suffering from cardiac disease cannot receive contrast agent injections. The investigators have developed a totally non-invasive approach for quantifying myocardial perfusion. It is based on the magnetic labeling of arterial spins. Flowing into the capillaries (Arterial spin labeling, ASL).
Goal : The major goal of this research protocol is to validate a totally non-invasive method of myocardial blood flow quantification using MRI without contrast agent injection
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •People having no heart disease or treatment referred to cardiology
- •People having no cons -indications to MRI
- •People having no cons -indications to gadolinium ;
- •People not wearing implantable devices
- •People not wearing metallic foreign bodies or risk (eg . Business of steel, etc .. )
- •People having no cardiovascular risk factor
- •Person subject to the social security scheme
- •Nobody agreeing to participate in the study and who signed the informed consent
排除标准
- •Refusal to go spontaneous or MRI because of claustrophobia important
- •Trouble rhythm making MRI uninterpretable
研究组 & 干预措施
healthy volunteers
干预措施: Magnetic Resonance Imaging (MRI) (Device)
healthy volunteers
干预措施: sodium-23 MRI (Device)
healthy volunteers
干预措施: phosphorus-31 Magnetic Resonance Spectroscopy (Device)
结局指标
主要结局
Myocardial perfusion
时间窗: 1day
MRI based on the magnetic labeling of arterial spins
次要结局
- the myocardial sodium(1day)
- the myocardial energetic status(1day)