Observational Study on Monitoring NSAID-Induced Gastropathy in Patients Using Magnetically-Controlled Capsule Gastroscopy
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 发起方
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Gastric diseases detected
研究概览
简要总结
The objective of this study is to observe gastric mucosal injuries in NSAID and non-NSAID users with magnetically-controlled capsule gastroscopy, and explore the effects of NSAIDs on gastric mucosal damage.
详细描述
Non-steroidal anti-inflammatory drugs are widely used in all kinds of people in China. A major limitation to their use is the adverse effects they cause on the gastrointestinal tract, including the formation of stomach lesions, ulcers due to stress reactions, and damage to the healing of gastric ulcers. The purpose of this prospective, single-center study was to monitor the gastric mucosal injury in patients with and without NSAIDs using magnetron capsule gastroscopy, and to explore the effect of NSaids on gastric mucosal injury.
For people taking NSAIDs, it is necessary to regularly detect gastric mucosal damage, and timely intervention treatment is required if relevant lesions are found, and the medication plan is adjusted. Magnetron capsule gastroscope has the advantages of comfort, safety, no anesthesia, no risk of cross infection, etc. It is highly accepted by the population, and is a beneficial supplement to traditional gastroscopy, so that some people with absolute or relative contraindications of traditional gastroscopy can get timely endoscopy, and can be diagnosed and treated early.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Planned magnetically-controlled capsule gastroscopy
- •NSAID use >3 months or no NSAID use
- •Informed consent
排除标准
- •No surgical conditions or refuses abdominal surgery (Once the capsule is stuck it cannot be removed surgically);
- •Cardiac pacemakers (except MRI-compatible ones);
- •Electronic implants or metal foreign bodies;
- •Pregnant women;
- •Known or suspected GI obstruction, stenosis, fistula;
- •Dysphagia.
结局指标
主要结局
Gastric diseases detected
时间窗: 1 day
Gastric diseases detected
次要结局
- Effects of NSAID dosage on gastric injury(1 day)
- Gastric mucosal injury by Lanza score(1 day)
- Gastric transit time(1 day)
- Effects of NSAID duration on gastric injury(1 day)
- Gastric cleanliness(1 day)
研究者
Xiaobo Li
Chief physician
Shanghai Jiao Tong University School of Medicine
