Testicular Function After Testicular Torsion
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 140
- 试验地点
- 1
- 主要终点
- Sperm concentration
研究概览
简要总结
The purpose of this study is to evaluate testicular function measured as testosterone level and semen quality.
详细描述
Men having undergone surgery for testicular torsion between 01.01.2003 - 12.31.2012 will receive a invitation to participate in this study. It is expected that 110 patients can be identified and about 65% of them will participate. These men will undergo a andrological evaluation, deliver a semen sample, have a blood sample taken and undergo a testicular ultrasound.
Control group:
Men attending the fertility counseling at Herlev hospital will be offered participation in this study. The fertility counseling demands that men who contact the clinic have never had their sperm analyzed, have not tried to get pregnant with their partner for more than a year and that they have no prior knowledge of their fertility.
Primary endpoint:
- Semen quality measured as sperm concentration
- Total testosterone level
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Men with a verified testicular torsion operated at Herlev and Gentofte hospital between 01.01.2003 and 12.31.2012
排除标准
- •Retentio testis
- •Varicocele
- •Previous treatment with chemo- or radiation therapy
- •Genetic disposition for infertility
- •Anejculation
- •Retrograde ejaculation
结局指标
主要结局
Sperm concentration
时间窗: 8-17 years after surgical intervention
Amount of motile sperm cells (\* 10\^6)
Testosterone level
时间窗: 8-17 years after surgical intervention
ng/ml
次要结局
- Semen parameters as an indicator of overall testicular exocrine function(8-17 years after surgical intervention)
- Hormone level as an indicator of testicular endocrine function(8-17 years after surgical intervention)
- MAR test result correlated to the type of surgery(8-17 years after surgical intervention)
- Difference in sperm morphology and motility correlated to the type of surgery and compared to control group(8-17 years after surgical intervention)
- Paternity as a measure of fertility(8-17 years after surgical intervention)
研究者
Frederik Møller Jacobsen
Principal Investigator
Herlev and Gentofte Hospital