NCT06047938尚未招募不适用
Familial Mediteranean Fever in Upper Egypt, and Its Relation to Atherosclerosis in Children
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 主要终点
- detecting subclinical atheroscelerosis
研究概览
简要总结
The aim of this study is to search for subclinical atherosclerosis in children diagnosed as FMF in Assiut University children's Hospital, and to correlate the risk to develop atherosclerosis to the different characters and genetic variants of FMF.
详细描述
- To describe the clinical characteristics of patients diagnosed as FMF in Upper Egypt, and to find the most common presenting symptoms.
- To mention the most common genetic variants reported in FMF patients in Upper Egypt, and to correlate the genetic variant with the risk to develop atherosclerosis.
- To assess the growth parameters in patients with FMF and compare it with the control group.
- To estimate the differences in Complete blood count (CBC) parameters, lipid profile, CIT in patients with FMF and control group.
- To search for subclinical atherosclerosis in patients with FMF based on their lipid profile and CIT.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 1 Year 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age at enrollment less than18 years.
- •Both sexes.
- •Diagnosed as familial Mediterranean fever according to Tel Hashomer criteria. [10]
排除标准
- •Patients with acute or chronic active infections.
- •Patients with pre-existing illness as chronic lung, liver or renal diseases.
- •Patients with diabetes mellitus, atherosclerotic vascular disease.
- •Patients with malignancy
结局指标
主要结局
detecting subclinical atheroscelerosis
时间窗: It will be measured in one year
The aim of this study is to detect subclinical atherosclerosis in children diagnosed as FMF in Assiut University children's Hospital by measuring carotid intima thickness
次要结局
未报告次要终点
研究者
Ali AbdElhaleem Hussein
Doctor
Assiut University
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