NCT00736801已完成不适用
Effect of Salmeterol on Brain-Derived Neurotrophic Factor (BDNF) Concentrations in Asthma
University of Rostock1 个研究点 分布在 1 个国家目标入组 35 人开始时间: 2005年9月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- BDNF concentrations in serum, platelets and plasma
研究概览
简要总结
BDNF has been linked to the pathogenesis of airway hyperresponsiveness in asthma. In this trial, the impact of a treatment with salmeterol and salmeterol / fluticasone on BDNF concentrations will be assessed in patients with asthma. The investigators hypothesize that salmeterol impacts on BDNF concentrations in patients with asthma.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years, a physician's diagnosis of allergic asthma
- •A documented sensitization to aero-allergens (pollen, animal hair, or house dust mite)
- •A pre-bronchodilator forced expiratory volume in the first second (FEV1) > 80 % of the predicted value (% predicted), a provocative concentration of histamine causing a 20 % fall in FEV1 (PC20) of < 8 mg histamine / ml
排除标准
- •No regular treatment (only short-acting inhalers on demand were allowed)
- •No history of or evidence for any other chronic disease than asthma
- •No history of smoking, absence of any signs or symptoms of an infection
研究组 & 干预措施
A
Experimental
Treatment with Salmeterol for 2 weeks, followed by a treatment with Salmeterol and Fluticasone for 2 weeks.
干预措施: Salmeterol and Salmeterol / Fluticasone (Drug)
结局指标
主要结局
BDNF concentrations in serum, platelets and plasma
时间窗: 2006 - 2007
次要结局
- Airway hyperresponsiveness(2006 - 2007)
研究者
研究点 (1)
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