CTRI/2025/02/080173已完成2 期
Evaluating therapeutic efficacy of N acetylcysteine in reducing organ dysfunction and mortality in acute paraquat poisoning an open label, parallel-group randomised control trial
Postgraduate Institute OF Medical Education and Research1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2025年2月20日最近更新:
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- prevention acute respiratory distress syndrome and reducing its severity
研究概览
简要总结
THIS IS AN OPEN LABEL PARALLEL GROUP, RANDOMISED CONTROL TRIAL TO BE CONDUCTED IN INDIA’S TERTIARY CARE CENTRE PGIMER CHANDIGARH. THIS STUDY EVALUATES THERAPEUTIC EFFICACY OF N ACETYLCYSTEINE IN REDUCING ORGAN DYSFUNCTION AND MORTALITY IN ACUTE PARAQUAT POISONING.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •patients aged morethan 18 years with history of ingestion (oral route) of paraquat till 5 days.
排除标准
- •only inhalational and dermal exposure to paraquat 2)pregnant females 3)chronic lung disease (COPD&ILD) 4)chronic kidney disease 5) COVID-19-Positive patients 6)paracetamol poisoning where N acetylcysteine is to be given as treatment 7)multiple poisonous compounds consumption like organophosphorus and paraquat poisoning.
结局指标
主要结局
prevention acute respiratory distress syndrome and reducing its severity
时间窗: after 14 days, the patient will be assessed for the organ failure or at the patient death for mortality
次要结局
- 1)reducing the incidence of acute kidney injury(2)reducing occurrence of acute liver injury)
研究者
Dr Cheekatla Venkata Santosh
Postgraduate Institute OF Medical Education and Research
研究点 (1)
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