NCT01121003已完成不适用
Effects of a Weight Maintenance, High Fructose Diet and of Exercise on Hepatic Lipid Metabolism
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- Hepatic de novo lipogenesis
研究概览
简要总结
8 healthy male volunteers will be studied each on 3 occasions, ie
- after 4 days on a weight maintenance diet containing 5% simple sugars + low physical activity
- after 4 days on a weight maintenance diet containing 30% fructose + low physical activity
- after 4 days on a weight maintenance diet containing 30% fructose + high physical activity At the end of each of these 3 periods, fructose induced hepatic de novo lipogenesis (13C palmitate synthesis in response to ingestion of a 13C fructose load) and plasma VLDL-triglyceride kinetics (measured with a bolus of 2H-labeled glycerol) will be measured
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •age between 18 and 30 years
- •BMI between 19 and 25
- •low to moderate physical activity (< 3 sessions/week)
排除标准
- •consumption of alcohol>50g/week
- •consumption of drugs or illicit substances
- •food allergies
研究组 & 干预措施
Low fructose diet/no exercise
Other
干预措施: weight maintenance, low sugar diet (Behavioral)
high fructose diet/no exercise
Experimental
干预措施: weight maintenance, high fructose diet (Behavioral)
high fructose diet+exercise
Experimental
干预措施: weight maintenance, high fructose diet+ exercise (Behavioral)
结局指标
主要结局
Hepatic de novo lipogenesis
时间窗: after 4 days on controlled diet+exercise
Measurement of 13C VLDL palmitate after ingestion of 13C fructose
次要结局
- Plasma VLDL-triglyceride kinetics(after 4 days on controlled diet+exercise)
研究者
Luc Tappy, MD
Professor of Physiology
University of Lausanne
研究点 (1)
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