Myocardial Perfusion Imaging by Combined 15O-H2O PET and MR for Evaluation of Reversible Myocardial Ischemia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 73
- 试验地点
- 1
- 主要终点
- Prognostic value within 10 years
研究概览
简要总结
The trial will include 75 patients with evident or suspected ischemic heart disease refered to Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, for perfusion imaging by 15O-H2O PET/CT scan of the heart during rest and stress. Instead of the clinical scan participants will undergo perfusion imaging by 15O-H2O PET/MR.
The clinician will receive diagnostic information based on the 15O-H2O PET scan as if the patient had not participated in the study. As such, the study has no influence on the diagnostics or treatments of the patient.
Data from the scans will be used to compare 15O-H2O PET with cardiac MR for evaluation of myocardial perfusion.
Follow up will be done for up to 10 years in regards to major cardiovascular events in order to determine the prognostic value of the scan.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Refered for myocardial perfusion imaging by O15-H2O PET at Department of Nuclear Medicine & PET Centre, Aarhus University Hospital
- •> 18 years of age
排除标准
- •Allergic to adenosine
- •Allergic to gadolinium
- •Pregnancy
- •Claustrophobia
- •Severe Asthma
- •Pacemaker or other ferro-magnetic implants
- •GFR < 30
结局指标
主要结局
Prognostic value within 10 years
时间窗: 10 years
Number of participants who experience a major adverse cardiac event within 10 years of follow-up.
Difference in myocardial blood flow
时间窗: 2 years
The difference in assessed myocardial blood flow as measured by 15O-H2O PET and MR
次要结局
- Prognostic value within 3,5 years(5 years)
- Difference in predictive value(10 years)
- Difference in left ventricular mass(2 years)
- Pulmonary transit time(2 years)
- Difference in coronary flow reserve(2 Years)
- Difference in right ventricular end-diastolic volume(2 years)
- Pulmonary perfusion(2 years)
- Difference in left ventricular end-systolic volume(2 years)
- Difference in left ventricular end-diastolic volume(2 years)
- Difference in right ventricular end-systolic volume(2 years)
- Amount of scar tissue(2 years)