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临床试验/NCT02885493
NCT02885493已完成不适用

The Elderly 's Parkinsonian March : Risk Estimation Multiple Drops From an Evaluation Grid Covering the March, Executive Functions, Vision and Anxiety.

University Hospital, Strasbourg, France1 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2015年3月20日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
80
试验地点
1
主要终点
falls risks

研究概览

简要总结

The strong relationship between falling and severity of cognitive impairment in the elderly is well established. The association premorbid gait and executive disorders suggests that they are under tension by the same mechanisms. The gait fortiori neurological are fall risk factors. Dysfunctions underlying disorders as Parkinson called march executive disorders are subcortical origin involving so the basal ganglia. This study is indeed based on the assumption that the dysfunction of the basal ganglia as observed in parkinsonian syndromes resulting in disorders of posture and walking, by dysexecutive syndrome, anxiety and the contrast vision disorders. These gait exposed to falls and dysexecutive these disorders with cognitive impairment and greater susceptibility to confusional states. The executive disorders, gait disorders, anxiety, disturbances of vision and especially saccadic eye movements, impaired vision contrasts are well established in the degenerative parkinsonian syndromes. This study proposes a new approach to assessing gait disorders to define a high risk of falling in the presence of parkinsonian walking in the elderly over 75 years.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
65 Years 至 —(Older Adult)
性别
All
接受健康志愿者

入选标准

  • Age: 75 years,
  • man or woman,
  • Diagnostic Criteria for Parkinson walking: at least 3 of the following symptoms:
  • Loss of swinging arms,
  • Decrease in stride walking slowly,
  • feet as glued to the ground,
  • piece U-turn,
  • kyphotic Attitude,
  • Tolerance screw physiotherapy screws

排除标准

  • Unrecovered delirium,
  • Unable to walk for a distance of 6 meters in length without technical assistance,
  • Traumatic fall phase of rehabilitation,
  • Acute pathology,
  • Unstabilized psychiatric pathology,
  • Symptomatic orthostatic hypotension,
  • Severe depressive syndrome untreated
  • Subjects with a sufficient gap to explain the falls:
  • cerebellar syndrome,
  • a pyramidal syndrome with sequelae pyramidal deficit and cortical stroke
  • peripheral pathology,
  • rheumatic disease,
  • orthopedic pathology,
  • Mini Metam State Examination <18,
  • Parkinsonism induced by neuroleptics,
  • Not cured cancer,
  • Psychotropic drugs (benzodiazepines and antipsychotics) with significant sedative effect inducing excessive daytime sleepiness namely psychotropic half long life, and high dose over 2 psychotropic
  • Severe heart failure
  • Severe respiratory failure,
  • Associated diseases and treatments interfering

结局指标

主要结局

falls risks

时间窗: number of falls during follow-up of 24 months

Assess Falls development risk in the presence of parkinsonian walking

次要结局

  • number of confusional states(follow-up of 24 months)
  • number of hospitalizations(follow-up of 24 months)
  • mortality(follow-up of 24 months)

研究者

发起方
University Hospital, Strasbourg, France
申办方类型
Other
责任方
Sponsor

研究点 (1)

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