Association of Transcutaneous Pulse CO-oximetry With Inflammatory Lung Diseases
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 59
- 试验地点
- 1
- 主要终点
- SpCO comparison: uncontrolled asthma v. other groups
研究概览
简要总结
This is a pilot cross-sectional study of measured transcutaneous CO-oximetry in children with inflammatory and non-inflammatory conditions.
详细描述
Children and young adults age 6-24 with the following conditions: asthma, pneumonia, allergic rhinitis, cystic fibrosis, and well child (without inflammatory illness) will be recruited.
Subjects will be asked to complete a brief screening survey to determine if they meet inclusion criteria. Enrolled subjects will be asked to complete questionnaire forms to characterize their health, current symptoms, medications, and common exposures. Transcutaneous carboxyhemoglobin will be recorded.
This study is cross-sectional and will only require one visit coinciding with the clinical visit. Analysis will determine the pairwise differences in SpCO between conditions tested.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 6 Years 至 24 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •diagnosis of asthma, pneumonia, allergic rhinitis, or none of the previous (control group)
- •Ability to complete study procedures
排除标准
- •Cardiopulmonary disease outside of the specific conditions for inclusion
- •Prematurity
- •Congenital heart disease
- •Current diagnosis of more than one of the following: asthma, pneumonia, allergic rhinitis, cystic fibrosis, or - for controls - any current infection
- •Recent serious bacterial infection (except for pneumonia in the pneumonia group)
- •Concurrent clinical chest X-ray with findings other those that expected for the group (i.e. normal chest X-ray in pneumonia group or suspected pneumonia on chest X-ray in asthma group). To be determined by attending radiologist's interpretation.
结局指标
主要结局
SpCO comparison: uncontrolled asthma v. other groups
时间窗: Time of visit
A pairwise comparison of mean SpCO will be performed between asthma exacerbation group and each other group, e.g., asthma exacerbation v. stable asthma, asthma exacerbation v. pneumonia, etc. An independent t-test will be used to determine statistical significance of the difference of means.
次要结局
未报告次要终点
研究者
Jonathan M. Gaffin
Principal Investigator
Boston Children's Hospital