Diagnostic Value of Serum Cathepsin S and Chromogranin A in Diabetic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 92
- 主要终点
- Evulate the diagnostic value of serum cathepsin S and chromogranin A for Diabetic kidney disease.
研究概览
简要总结
- Evulate the diagnostic value of serum cathepsin S and chromogranin A for Diabetic kidney disease.
- To correlate the levels of serum Cathepsin S and chromogranin A with HbA1c and eGFR in type 2 diabetic patients based on urinary Albumin- Creatinine Ratio.
详细描述
Diabetic nephropathy (DN) is a common and serious complication of diabetes and has been shown to be a major cause of end-stage renal disease (ESRD), requiring costly renal replacement therapy in the form of dialysis or transplantation .
It is appreciated that up to 40% of patients with type 1 and type 2 diabetes mellitus (DM) present DN . Early detection and appropriate treatment are essential to prevent disability and death.
Cathepsin S (Cat-S) was a secreted cysteine proteolytic enzyme that is mainly expressed in macrophages. Macrophages undergoing chemotaxis adhere to the basement membrane of blood vessels and secrete Cat-S, and the secreted Cat-S was involved in hydrolysis of elastin, laminin, collagen and other extracellular matrix components, causing vascular damage .
So, Cathepsin S(Cat-S), a novel non-invasive diagnostic marker mediates vascular endothelial dysfunction.
In recent years, studies have shown that up regulation of Cat-S was associated with the development of IgA nephropathy, lupus nephritis, insulin resistance, diabetes and other renal diseases.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients diagnosed as type 2 Diabetes mellitus
- •Patients with T2DM with normoalbuminuria , microalbuminuria and macroalbuminuria.
排除标准
- •Renal impairment of other Known origin,
- •Type 1 D,
- •Hepatic disease,
- •Heart failure,
- •Thyroid disorders,
- •Autoimmune disorders,
- •Inflammatory condition,
- •Malignancy,
- •Urinary tract infection,
- •Pregnancy.
结局指标
主要结局
Evulate the diagnostic value of serum cathepsin S and chromogranin A for Diabetic kidney disease.
时间窗: Baseline
Evaluation of the clinical utility of the measurement of the level of Cathepsin S and chromogranin A in type 2 diabetic nephropathy.
次要结局
- correlate the levels of serum Cathepsin S and chromogranin A with HbA1c and eGFR in type 2 diabetic patients based on urinary Albumin- Creatinine Ratio.(Baseline)
研究者
Z A Kamel
principal investigator
Assiut University