Strategy for Management of Patients With Hereditary Cancer Syndromes (HCS) in a Rural Environment
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Adherence to Cancer Prevention and Surveillance Guidelines
研究概览
简要总结
This study aims to improve cancer prevention and surveillance adherence in patients with Hereditary Cancer Syndromes (HCS), particularly those living in rural areas. The study will evaluate whether enrolling HCS patients in a longitudinal clinical program with individualized care plans and regular follow-up improves adherence to guideline-recommended cancer screening and risk-reduction strategies. Secondary aims include assessing the program's impact on patient distress and perceived care coordination. The study will enroll 200 adults with known pathogenic germline mutations who were previously seen at the UVM Medical Center genetics clinic. Participants will complete surveys at baseline, 12, and 24 months to assess adherence, distress, and care coordination. Findings from this study will inform future efforts to reduce gaps in hereditary cancer care delivery, especially for rural populations.
详细描述
This single-arm, prospective, interventional study will assess the feasibility and impact of a structured longitudinal follow-up program for patients with Hereditary Cancer Syndromes (HCS). Eligible participants will have a known pathogenic germline variant in a cancer risk gene identified by a CLIA-approved lab at least one year prior to enrollment. All participants will be seen at baseline and followed clinically for two years, with additional visits as clinically indicated. Each participant will receive an individualized care plan developed by cancer genetics providers and supported by annual follow-up visits.
The primary objective is to assess whether participation in this program increases adherence to National Comprehensive Cancer Network (NCCN) guideline-recommended cancer screening and prevention strategies (e.g., surveillance imaging, colonoscopy, prophylactic surgery). Secondary objectives include evaluating changes in participant distress and perceived care coordination over time, and examining how rurality (defined using RUCA codes) affects outcomes.
Participants will complete three study instruments at baseline, 12-month, and 24-month follow-up visits:
A gene-specific adherence survey administered by the genetics team,
The Multidimensional Impact of Cancer Risk Assessment (MICRA) questionnaire to assess distress,
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients of all genders must be ≥ 18 years of age.
- •Patients must have a known pathogenic germline variant in a cancer risk gene that was identified by a CLIA-approved lab more than one year ago.
- •Patients must be able to accurately provide self-report data (i.e., per clinical judgment, cognitive function is intact).
- •Patients must be able to complete questionnaires in English.
- •Patients must have the ability to provide informed consent.
排除标准
- •- Patients who tested positive for a germline pathogenic variant associated with cancer risk < 1 year ago are not eligible.
研究组 & 干预措施
Longitudinal Cancer Genetics Follow-Up Program
Participants in this arm will be enrolled in a longitudinal cancer genetics follow-up program designed for individuals with known hereditary cancer syndromes (HCS). The intervention includes scheduled clinical visits with a cancer genetics physician and, as needed, a genetic counselor at baseline, 12 months, and 24 months. Participants will receive individualized care plans summarizing surveillance and prevention recommendations. Adherence, distress (MICRA), and care coordination (CCI) will be assessed through surveys administered at each visit.
干预措施: Longitudinal Cancer Genetics Follow-Up Program (Behavioral)
结局指标
主要结局
Adherence to Cancer Prevention and Surveillance Guidelines
时间窗: Baseline, 12 months, and 24 months
Proportion of participants who are adherent to National Comprehensive Cancer Network (NCCN) guideline-recommended cancer risk-reducing strategies-including surveillance imaging, colonoscopy, chemoprevention, and prophylactic surgeries-measured at baseline, 12 months, and 24 months. Adherence will be determined through a gene-specific adherence survey completed during clinic visits and supported by clinical documentation.
次要结局
- Change in Participant Distress Level as Measured by the MICRA Questionnaire(2 years)
- Change in Perceived Care Coordination(2 years)
研究者
Kara Landry
Assistant Professor of Oncology & Hematology
University of Vermont Medical Center