Airway Pressure During Nasal High Flow and CPAP in Neonates
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 10
- 试验地点
- 4
- 主要终点
- Upper airway pressure generated by NHF compared to CPAP
研究概览
简要总结
Nasal High Flow (NHF) and CPAP are established forms of respiratory support in neonates and often produce similar clinical outcomes. The aim of the study was to investigate airway pressure during NHF and CPAP in neonates.
详细描述
Methods: A physiological study which measured pressure intra-nasally with micro (750 µm) pressure probes (Millar, USA) in 10 (5M / 5F) healthy newborns with mean gestation age 37.18 (SD 1.29) wk and mean birth weight of 2414 (SD 503.13) g. NHF was applied at 8 L/min (AIRVO 2) through smaller (OPT 314) and larger (OPT 316) Optiflow nasal cannula; CPAP 5 cmH20 was produced by a Bubble CPAP system and nasal mask interface at constant flow 8 L/min (Fisher & Paykel Healthcare, NZ). Values are expressed in cmH20 as means and standard deviations (SD).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 1 Day 至 3 Days（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy term newborns
排除标准
- •Newborns with any medical problems after birth
- •Absent of parents consents
研究组 & 干预措施
Mask CPAP
CPAP 5cm H2O
干预措施: CPAP (Device)
no intervention
control
NHF small cannula
NHF 8 L/min (Airvo2) , Smaller cannula (neonatal, yellow)
干预措施: NHF small cannula (Device)
NHF big cannula
NHF 8 L/min (Airvo2) , Bigger cannula (neonatal, purple)
干预措施: NHF big cannula (Device)
结局指标
主要结局
Upper airway pressure generated by NHF compared to CPAP
时间窗: Up to 1 hour
Pressure in upper airways
次要结局
未报告次要终点