Chronic Obstructive Pulmonary Disease in Non Smokers:Role of Oxidative Stress
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- oxidative stress markers in non smokers COPD compared to healthy control
研究概览
简要总结
Background:Striking feature of Chronic obstructive pulmonary disease (COPD) is its inability to resolve after cigarette smoke exposure has ended, which has contributed to the possibility that the disease could also be driven by other endogenous causes, such as autoimmunity or chronic infection . Many of the pathogenetic pathways involved in COPD and its development tend to be driven by oxidative stress.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •1-Forty subjects of COPD who are non-smokers or stopped smoking for more than 6 months Based on the Global Initiative for Chronic Obstructive Lung Disease guidelines, COPD was diagnosed.9 2- Thirty subjects of non smokers healthy control
排除标准
- •Patients of:
- •Acute exacerbation, at the time of the study, of COPD.
- •Any obvious abnormal lung parenchymal lesions.
- •Lung cancer.
- •Congestive heart failure.
- •current smokers
- •Drugs e.g anti-inflammatory , steroids ,analgesics, insulin , antineoplastic, antipsychotic drugs in the previous 2 weeks before the study.
结局指标
主要结局
oxidative stress markers in non smokers COPD compared to healthy control
时间窗: 1month
markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) .
次要结局
未报告次要终点
研究者
zainab hassan saeed
principle investigator ,faculty of medicine,department of chest diseases,Minia University
Minia University