A Genome-Wide Association Study in Wilms Tumor
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1
- 试验地点
- 1
- 主要终点
- Frequency of maternal and paternal allelic transmission for risk alleles
研究概览
简要总结
This clinical trial studies gene analysis in studying susceptibility to Wilms tumor. Finding genetic markers for Wilms tumor may help identify patients who are at risk of relapse.
详细描述
PRIMARY OBJECTIVES:
I. To use a genome-wide association analysis to identify novel genetic variants that confer susceptibility to Wilms tumor.
II. To improve our understanding of the genetic architecture and etiology of Wilms tumor.
III. To facilitate the identification of genetic markers that are associated with an increased risk of developing of Wilms tumor and/or those at risk of aggressive disease, relapse, additional tumors and/or cancer in their offspring.
OUTLINE:
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •3000 samples from the 1958 Birth Cohort (58C) and 3000 from the UK Blood Service control series (NBS)
排除标准
- 未提供
结局指标
主要结局
Frequency of maternal and paternal allelic transmission for risk alleles
时间窗: Baseline
Compared using a chi-squared test.
Interactions between genetic variation and treatment success or prognosis
时间窗: Baseline
Interactions between germline genetic variation and tumor phenotypes
时间窗: Baseline
Genetic variation on sub-phenotypes such as age at diagnosis, unilateral or bilateral disease, sex, and ethnicity
时间窗: Baseline
Frequencies between cases and controls at each SNP
时间窗: Baseline
Compared using the Cochran Armitage trend test (1-df). The data will be analyzed individually for the UK/US study populations and combined using a Mantel-Haenszel analysis adjusting for study group, and related methods which allow for different effects in each population (for confirmed loci, we will compare effects across populations).
次要结局
未报告次要终点