NCT03565601Unknown不适用
Phenotypic Features and Prognostic Value of Anti-Ro52 (TRIM-21) Antibodies in Connective Tissue Diseases
Central Hospital, Nancy, France2 个研究点 分布在 1 个国家目标入组 400 人开始时间: 2019年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 400
- 试验地点
- 2
- 主要终点
- ILD prevalence
研究概览
简要总结
Anti-Ro52 autoantibodies can be detected in patients with several autoimmune diseases. Clinical significance of anti-Ro52 is controversial. The presence of anti-Ro52 may be a factor associated with disease severity (interstitial lung disease, vasculopathy) and cancers. The aim of this study is to assess interstitial lung disease and vasculopathy prevalence and severity, cancers occurence and others clinical features of connective tissue disease patients with anti-Ro52 autoantibodies.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Connective tissue disease (differenciated or not)
- •Presence of anti-Ro52 antibodies at diagnosis
排除标准
- •Healthy subjects
结局指标
主要结局
ILD prevalence
时间窗: baseline (J0)
Clinical (cough, dyspnea) and/or radiological (tomodensitometry) data
次要结局
- Vasculopathy occurence(baseline (J0) and follow-up)
- Cancer occurence(baseline (J0) and follow-up)
- ILD severity(baseline (J0))
研究者
研究点 (2)
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