Effects of Cannabis on Prescription Drug Abuse Liability and Analgesia
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Subjective Effects
研究概览
简要总结
The purpose of this research is to assess the impact of cannabis on the analgesic and abuse-liability effects of a sub-threshold dose of a commonly used analgesic.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 21 Years 至 53 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or non-pregnant female aged 21-53 years
- •Previous cannabis use
- •Previous opioid use
- •Urine test positive for recent cannabis use
- •Being able to perform all study procedures
- •Currently practicing an effective form of birth control (women only)
排除标准
- •Meeting criteria for some Use Disorders
- •Report regular illicit drug use
- •If medical history, physical and psychiatric examination, or laboratory tests performed during the screening process revealed any significant illness
研究组 & 干预措施
Placebo
Participants will receive 0 mg oxycodone (oral) and placebo cannabis (vaporized)
干预措施: Placebo (Drug)
Oxycodone
Participants will receive 2.5 mg oxycodone (oral) and placebo cannabis (vaporized)
干预措施: Oxycodone (Drug)
Oxycodone
Participants will receive 2.5 mg oxycodone (oral) and placebo cannabis (vaporized)
干预措施: Placebo (Drug)
Cannabis (THC:CBD = ~1:0)
Participants will receive 0 mg oxycodone (oral) and cannabis with high THC concentrations (vaporized)
干预措施: Placebo (Drug)
Cannabis (THC:CBD = ~ 0:1)
Participants will receive 0 mg oxycodone (oral) and cannabis with high CBD concentrations (vaporized)
干预措施: Placebo (Drug)
Cannabis (THC:CBD = ~ 1:1)
Participants will receive 0 mg oxycodone (oral) and cannabis with equal CBD and THC concentrations (vaporized)
干预措施: Placebo (Drug)
Cannabis (THC:CBD = ~1:0) + Oxycodone
Participants will receive 2.5 mg oxycodone (oral) and cannabis with high THC concentrations (vaporized)
干预措施: Oxycodone (Drug)
Cannabis (THC:CBD = ~ 0:1) + Oxycodone
Participants will receive 2.5 mg oxycodone (oral) and cannabis with high CBD concentrations (vaporized)
干预措施: Oxycodone (Drug)
Cannabis (THC:CBD = ~ 1:1) + Oxycodone
Participants will receive 2.5 mg oxycodone (oral) and cannabis with equal concentrations of THC and CBD (vaporized)
干预措施: Oxycodone (Drug)
结局指标
主要结局
Subjective Effects
时间窗: 6 weeks
Participants will rate "drug liking", "good drug effects", and "high" on a visual analogue scale (VAS; 1-100mm).
Cold Pressor Test
时间窗: 6 weeks
Participants will immerse their hand in a bucket of ice water to determine pain threshold and pain tolerance latencies (in seconds).
次要结局
未报告次要终点
研究者
Caroline A. Arout, Ph.D.
Research Scientist
New York State Psychiatric Institute