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临床试验/NCT02917889
NCT02917889Unknown不适用

Acute Caffeine Effects on Cardiac Autonomic and Cardiorespiratory Parameters Responses After Aerobic Exercise

Universidade Estadual Paulista Júlio de Mesquita Filho1 个研究点 分布在 1 个国家目标入组 35 人开始时间: 2015年2月最近更新:
适应症
干预措施
相关药物

试验速览

阶段
不适用
发起方
入组人数
35
试验地点
1
主要终点
Oxygen saturation pulse (oximeter-SpO2)

研究概览

简要总结

Check the acute influence of caffeine on the autonomic modulation and cardiorespiratory parameters after aerobic exercise. Hypothesized that caffeine can promote a slower recovery of the cardiorespiratory parameters and the SNA recovery after aerobic exercise.

详细描述

The experimental procedure is divided into three phases, all performed on a treadmill, with a minimum interval of 48 hours between them, in order to allow adequate recovery of the participants. Before the start of the first stage of the experimental protocol or control anthropometric measurements will be carried out, body weight by a digital scale (Plenna, TIN 00139 MAXIMA, Brazil)) and then, using a stadiometer (Plenna, TIN 00139 MAXIMA, Brazil)). The protocols are:

I) Maximum stress test protocol: assessment of the maximum oxygen consumption (VO2max) on a treadmill (Inbrasport / Millennium), using the Bruce protocol.

II) Control Protocol (PC): at this stage the volunteer will ingest compressed form of placebo similar to Protocol III and remained at rest after 15 minutes in the supine position, followed by 30 minutes of aerobic exercise on a treadmill, 5 minutes with speed 6.0 km / h followed by 25 minutes with 60% of VO2max and the final 60 minutes lying recovery.

III) Experimental protocol (PE): In this stage, the volunteer had performed activities similar to the PC, but will make the tablet intake consists of 300mg of caffeine, a value that is within the maximum daily amount allowed under the FDA.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 30 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • healthy men.

排除标准

  • cardiovascular, orthopedic, respiratory and neurological disorders reported or other pathological conditions that prevent the subject to perform the protocols;
  • smokers, alcoholics, or who use drugs that influence the activity of the heart.

研究组 & 干预措施

Caffeine protocol

Experimental

300 mg in pills

干预措施: Caffeine (Drug)

Caffeine protocol

Experimental

300 mg in pills

干预措施: Cardiopulmonary test (Other)

Caffeine protocol

Experimental

300 mg in pills

干预措施: Treadmill aerobic exercise (Other)

Placebo protocol

Experimental

300 mg in pills

干预措施: Placebo (Drug)

Placebo protocol

Experimental

300 mg in pills

干预措施: Cardiopulmonary test (Other)

Placebo protocol

Experimental

300 mg in pills

干预措施: Treadmill aerobic exercise (Other)

结局指标

主要结局

Oxygen saturation pulse (oximeter-SpO2)

时间窗: up to 1 year

Caffeine effects SpO2 recovery following aerobic exercise

Respiratory rate (per minute)

时间窗: up to 1 year

Caffeine effects arespiratory rate recovery following aerobic exercise

Caffeine effects on heart rate variability (based on frequency, time domain and Chaos)

时间窗: up to 1 year

Heart rate (beats per minute)

时间窗: up to 1 year

Caffeine effects heart rate recovery following aerobic exercise

Blood pressure (mmHg)

时间窗: up to 1 year

Caffeine effects blood pressure recovery following aerobic exercise

次要结局

未报告次要终点

研究者

发起方
Universidade Estadual Paulista Júlio de Mesquita Filho
申办方类型
Other
责任方
Principal Investigator
主要研究者

Luana Almeida Gonzaga

Principal Investigator

Universidade Estadual Paulista Júlio de Mesquita Filho

研究点 (1)

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