EURO SHOCK Testing the Value of Novel Strategy and Its Cost Efficacy in Order to Improve the Poor Outcomes in Cardiogenic Shock
试验速览
- 阶段
- 不适用
- 入组人数
- 428
- 试验地点
- 93
- 主要终点
- All-cause mortality at 30 days
研究概览
简要总结
Cardiogenic shock (CGS) affects up to 10% of patients suffering acute coronary syndrome. It has a 30 day mortality of 45-50%. No pharmacological nor intervention/device trials have had any impact on this mortality in the last 20 years.
The EURO SHOCK Trial (supported by the European Union Horizons 2020 programme) will randomise 428 patients with CGS following acute coronary syndrome from 44 EU centres to early intervention with Extra Corporeal Membrane Oxygenation (ECMO) therapy or to standard treatment (with no ECMO). This intervention is a high cost specialist centre procedure that warrants further investigation including economic appraisal. Multiple mechanistic and hypothesis generating sub-studies will be undertaken.
详细描述
The EURO SHOCK trial tests the novel use of early deployment of mechanical support device in Cardiogenic Shock (CGS) in a randomised, strategy trial, with evidence of benefit or otherwise measured by recording hard clinical end-point outcomes.
Extra Corporeal Membrane Oxygenation (ECMO) is already used in CGS. This is therefore not a novel therapy. It is the use of ECMO early in the development of CGS that is the novel aspect of this project. The Investigators will test whether a strategy of very early ECMO can ameliorate the rapid decline that many CGS patients suffer. The value of deploying a clinically used and approved device prospectively and early in the natural history of CGS compared to standard practice has not been tested before and will be the basis of the EURO SHOCK project.
This trial itself will be a prospective randomized, open label, design study that will compare two groups of patients: Both will receive appropriate percutaneous coronary intervention (PCI) as is current practice as they arrive at the hospital.
- Group 1 will receive immediate PCI + standard care (pharmacological support).
- Group 2 will receive immediate PCI plus support with early peripheral veno-arterial ECMO + standard care (pharmacological support).
The Investigators will also compare the cost-effectiveness of early VA-ECMO, as compared to current standard of care. EURO SHOCK will also evaluate novel CMR protocols in these unwell patients, and also whether systems of urgent flagged transfer of the unwell patient is practical and beneficial. The Investigators will determine whether there are biological and ECG markers that predict worse patient outcomes, which could thus help select most appropriate patients for expedited treatments (the patient is only transferred if needed).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Willing to provide informed consent/assent.
- •Presentation CGS within 24 hours of onset of Acute Coronary Syndrome (ACS) symptoms.
- •CGS can only be secondary to ACS (Type 1 MI STEMI or N-STEMI) or secondary to ACS following previous recent PCI (acute/sub-acute stent thrombosis ARC)
- •PCI has been attempted.
- •Persistence of CGS 30 minutes after successful or unsuccessful revascularisation of culprit coronary artery to allow for echocardiography and clinical assessment.
- •CGS will be defined by the following 2 criteria:
- •Systolic blood pressure <90 mmHg for at least 30 minutes, or a requirement for a continuous infusion of vasopressor or inotropic therapy to maintain systolic blood pressure > 90 mmHg.
- •Clinical signs of pulmonary congestion, plus signs of impaired organ perfusion with at least one of the following manifestations:
- •altered mental status.
- •cold and clammy skin and limbs.
- •oliguria with a urine output of less than 30 ml per hour.
- •elevated arterial lactate level of >2.0 mmol per litre.
- •Provision of informed assent followed by patient consent; [or relative or physician consent if the patient is unable to consent].
排除标准
- •Unwilling to provide informed assent/consent.
- •Echocardiographic evidence) of mechanical cause for CGS: eg ventricular septal defect, LV-free wall rupture, ischaemic mitral regurgitation (recorded within 30 mins of end of PCI procedure).
- •Age <18 and>90 years.
- •Deemed appropriately frail (≥ 5 Canadian frailty score)
- •Shock from another cause (sepsis, haemorrhagic/hypovolaemic shock, anaphylaxis, myocarditis etc.).
- •Significant systemic illness
- •Known dementia of any severity.
- •Comorbidity with life expectancy <12 months.
- •Severe peripheral vascular disease (precluding access making ECMO contra- indicated).
- •Severe allergy or intolerance to pharmacological or antithrombotic anti-platelet agents.
- •Out-of-hospital cardiac arrest (OHCA) under any of the following circumstances:-
- •without return of spontaneous circulation (ongoing resuscitation effort).
- •without pH or >7 without bystander CPR within 10 minutes of collapse.
- •Involved in another randomised research trial within the last 12 months.
- •Arterial lactate level of <2.0 mmol per litre.
结局指标
主要结局
All-cause mortality at 30 days
时间窗: at 30 days
Death from any cause
次要结局
- All-cause mortality or admission for heart failure at 12 months(at 12 months)
- All-cause mortality at 12 months(at 12 months)
- Admission for heart failure at 12 months(at 12 months)