NCT01785550已完成不适用
Ultrasonography in Amyotrophic Lateral Sclerosis as a Predictor of Disease Progression and Tool in Diagnosis: a Pilot Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Abnormalities at onset: Ultrasound vs. Electromyography
研究概览
简要总结
Amyotrophic Lateral Sclerosis (ALS) is a progressive fatal neurodegenerative disease affecting motor neurons. Early diagnosis is essential for the success of clinical trials and objective biomarkers are needed for monitoring disease progression. Nerve and muscle ultrasound may provide this information.
This study will collect pilot data to evaluate the value of muscle and nerve ultrasound to identify and monitor disease progression in ALS.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects referred to the electromyography laboratory for ALS.
排除标准
- •Patients with known comorbid myopathy or neuropathy will be excluded from the study.
- •Patients unable to provide their own consent will be excluded.
结局指标
主要结局
Abnormalities at onset: Ultrasound vs. Electromyography
时间窗: 1 year
Ultrasound measures will be compared to electromyography measures at the patient's initial assessment. The number of abnormal muscles will be counted using each technique and analyzed to determine if one test is superior.
次要结局
- Ultrasound Predicting Outcome at 1 year(1.5 years)
研究者
研究点 (1)
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