Efficacy of Intranasal Ketamine and Dexmedetomidine on Postoperative Pain and Swelling Following Impacted Mandibular Third Molar Surgery A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- To evaluate the reduction in Pain and Swelling after impacted mandibular third molar surgery
研究概览
简要总结
The aim of this study is to “Evaluate the effect of intranasal Ketamine and intranasal Dexmedetomidine on Pain and Swelling in patients undergoing impacted mandibular third molar surgery .â€To evaluate the clinical outcomes of intranasal Ketamine and intranasal Dexmedetomidine on Pain, Swelling, Trismus after third molar surgery, to evaluate the sedative effect of intranasal Ketamine and intranasal Dexmedetomidine during third molar surgery and to evaluate the effect on perioperative hemodynamic parameters like Blood pressure, Pulse rate, Respiratory rate and Sp02.
Inclusion criteria:Patients of age 18 - 40 years, patients with bilaterally similar impacted mandibular third molars, systemically healthy patients, ASA class I & II, patients willing to give an informed consent, patients not receiving any pain medication.
Using a split mouth study design ,bilaterally impacted third molars shall be removed in two different appointments. [2 weeks]
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with bilaterally similar impacted mandibular third molars
- •Systemically healthy patients, ASA class I & II 3.Patients willing to give an informed consent .
- •Patients not receiving any pain medication.
排除标准
- •Allergic to Ketamine and Dexmedetomidine
- •Patients not willing to give an informed consent
- •Acute inflammation or infection at the site of surgery
- •Allergic rhinitis, nasal pathologies
- •Pregnant and lactating women
- •Bradycardia
- •Renal or hepatic disease
- •Patients with a BMI of more than 27 kg/m2.
结局指标
主要结局
To evaluate the reduction in Pain and Swelling after impacted mandibular third molar surgery
时间窗: Reduction in Pain-1,6,12,24,48 hrs postoperatively. | Reduction in Swelling- 2nd and 7th postoperative day.
次要结局
未报告次要终点
研究者
Dr Bandi Sreenivasulu
Vishnu Dental College