Skin Microcirculation Evaluation With Nailfold Capillaroscopy in Cushing's Syndrome Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Nailfold capillary avascular areas
研究概览
简要总结
This cross-sectional, single-center study will assess the microvascular function using a nailfold video-capillaroscopy in patients with endogenous Cushing syndrome.
详细描述
Endogenous Cushing's syndrome (CS) is associated with increased macrovascular diseases and impaired endothelial function. There is no clear data about the effects of hypercortisolism on microcirculation.
The primary aim of this study is to evaluate the peripheric microvascular area in patients with Cushing's syndrome. The association of microvascular changes with present comorbidities (diabetes, hypertension, etc.) and disease activation will be evaluated.
Method:
Cushing syndrome patients admitted to our clinic will be included in this study for the next six months after given informed consent.
The following clinical laboratory parameters will be evaluated as cross-sectionally.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male and female patients diagnosed as Cushing syndrome (CS) caused by ACTH-producing pituitary adenoma or cortisol producing adrenal adenoma
- •Age between 18 and 70 years
排除标准
- •Chronic glucocorticoid use
- •CS caused by ectopic ACTH producing tumors
- •CS caused by adrenocortical carcinoma
- •Pseudo CS
- •Patients with Raynaud phenomenon
- •Patients with collagen tissue disease
- •Patients who use drugs that affect the metabolism of fibrinolysis (such as oral contraceptives)
- •Employees at work at risk of microtrauma (such as gardeners, farmers)
- •Skin diseases with nail fold involvement (such as dermatitis, psoriasis)
结局指标
主要结局
Nailfold capillary avascular areas
时间窗: 6 months
Nailfold capillary area changes
Nailfold capillary number of tortuous loops
时间窗: 6 months
Nailfold capillary area changes
Nailfold capillary area number of meandering capillaries
时间窗: 6 months
Nailfold capillary area changes
次要结局
- Correlation between nailfold capillary number of tortuous loops and presence of diabetes(6 months)
- Correlation between nailfold capillary number of tortuous loop with urine free cortisol levels(6 months)