Seroprevalence of Brucella Antibodies in High-Risk Patients With Low Back Pain: A Case-Control Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Prevalence of Brucella Antibodies in High-Risk Patients with Low Back Pain
研究概览
简要总结
The goal of this observational case-control study is to assess the presence of Brucella antibodies in patients with low back pain who are at high risk for brucellosis exposure, such as those with animal contact or consumption of unpasteurized dairy products. The main question it aims to answer is:
Is there a significant association between Brucella seropositivity and low back pain in high-risk individuals?
Researchers will compare patients with low back pain to age- and sex-matched healthy controls without back pain but with similar exposure risks, to see if Brucella antibodies are more frequent in the patient group.
Participants will:
Undergo a detailed clinical history and physical examination
Provide blood samples for serological testing using ELISA for Brucella IgG/IgM/IgA
Be evaluated for other symptoms such as fever, fatigue, and joint pain
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults of any sex at high risk of Brucella exposure (e.g., contact with livestock or consumption of unpasteurized dairy products)
- •Patients presenting with non-specific low back pain
- •Willing and able to provide informed consen
排除标准
- •Evidence of tuberculosis (Pott's disease)
- •Evidence of septic spondylitis
- •Known metastatic bone lesions
- •Known degenerative or autoimmune rheumatologic spinal diseases
- •History of prior spinal surgery or trauma
结局指标
主要结局
Prevalence of Brucella Antibodies in High-Risk Patients with Low Back Pain
时间窗: At enrollment
The presence of Brucella antibodies (IgG, IgM, and IgA) in serum was assessed using the SERION ELISA classic Brucella kit. A positive result indicates prior or current exposure to Brucella species. The outcome compares the proportion of seropositive individuals between patients with low back pain and matched controls.
次要结局
未报告次要终点
研究者
Elham Ahmed Hassan
Professor of Tropical Medicine and Gastroenterology, Assiut University
Assiut University