Structural and Microbiological Characterization of Arterial Catheter Biofilm in ICU's Patients Using Optical Coherence Tomography
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Biofilm structure type (ribbon-shaped or mushroom-shaped), measured with D-FF-OCT
研究概览
简要总结
29.3% of bacteremias in intensive care units (ICU) are linked to vascular devices, including 7.7% to arterial catheters, with an influence on both morbility and mortality.
It is now accepted that biofilm as a role on bacterial development on inner surface of vascular devices but there is yet a lack of clinical relevant data documenting a causal relation between biofilm formation and bacteremias.
The investigators assume that a better structural and microbiological characterization of arterial catheter biofilm in ICU patients could help preventing bacteremias or have a more specific treatment when it appears.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient or relative informed of the study and having declared their non-objection
- •Patient over 18 years old
- •Patient hospitalized in ICU with an arterial catheter
排除标准
- •Patient unable to express consent
- •Patient whose collection of the arterial catheter is impossible or for whom storage at 4°C is impossible
- •Patient with arterial catheter removed outside the usual procedure of the ICU
- •Patient admitted in ICU with an arterial catheter already in place
研究组 & 干预措施
OCT-BIO-KTA cohort
Critically ill patient > 18 years of age with artherial catheter for >2 calendar days in ICU
干预措施: OCT-BIO-KTA cohort (Other)
结局指标
主要结局
Biofilm structure type (ribbon-shaped or mushroom-shaped), measured with D-FF-OCT
时间窗: Outcome measure is assessed 2 days following catheter removal
Provide a better understanding of the relation between structural and microbiological characterization of artherial catheter biofilm in ICU patients using D-FF-OCT
次要结局
- Bacterial or fungal indentification(Outcome measure is assessed 2 days following catheter removal)
- Biofilm thickness, measured with D-FF-OCT(Outcome measure is assessed 2 days following catheter removal)
- Biofilm dynamic signal distribution, measured with D-FF-OCT(Outcome measure is assessed 2 days following catheter removal)