Melatonin Against Temazepam in Comparing adverse events in vulnerable elderly Hospitalized patients with sleeping problems - MATCH

Academisch Medisch Centrum0 个研究点目标入组 717 人开始时间: 待定最近更新: 2024年4月23日

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•- aged 65 years or older
•- acutely admitted for a medical or surgical reason
•- experiencing new onset or aggravated sleep problems, for which the patient/nurse/treating physician expresses a need for intervention
•- willing and medically able to receive therapy according to the protocol for the duration of the study
•- able to fill out the sleep questionnaire that serves as primary outcome measurement (Leeds Sleep
•Evaluation Questionnaire)
•- agreeing to informed consent

•- no understanding of Dutch or English
•- lack of decision making capacity
•- previously diagnosed with dementia
•- transferred from another hospital to one of the study centres
•- transferred from another ward (ICU, CCU etc) to one of the study wards
•- expected stay in hospital of <48 hours
•- concurrent regular benzodiazepine use (>1 doses/week)
•- concurrent regular melatonin use (>1 doses/week)
•- alcohol consumption >13 units/week for women and >20 units/week for men(24)
•- concurrent use of: chinolones, rifampicine, fluvoxamine, carbamazepine
•- having a medical condition that is a contra indication for benzodiazepine use (allergy to benzodiazepines, hepatic failure (Child-Pugh C), kidney disease requiring dialysis, risk of respiratory depression (as clinically esteemed so by the attending physician)

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