JPRN-UMIN000015403已完成4 期
Effect of Topiroxostat on Urinary Albumin in hyperuricemic patients with Diabetic nephropathy - ETUDE study
Department of Nephrology, Nagoya University Graduate School of Medicine0 个研究点目标入组 80 人开始时间: 2014年10月10日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 80
研究概览
简要总结
The changes in UACR after 24 weeks of treatment (or at the final time point if patients failed to reach 24 weeks) relative to the baseline were -122 mg/gCr (95% CI: -5.1 to -240.1, P = 0.041) in patients treated with high dose, while treatment with low dose topiroxostat could not show significant reduction (P = 0.067).
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1 Poor diabetic control 2 Patient have been treated with steroids 3 Patient with nephropathy excluding diabetic nephropathy (including: nephrosclerosis) 4 Cancer 5 Systemic disease with proteinuria (collagen disease, vasculitis and amyloidosis) 6 Gouty arthritis within 6 months 7 ALT, AST >= double as the standard of each hospital 8 Active Hepatitis C and/or C 9 Liver cirrhosis 10 Patients are deemed unsuitable by a physician
研究者
相似试验
已完成
2 期
Effect of Topiroxostat on Urinary Albumin Excretion Early Stage Diabetic Nephropathy and Hyperuricemia With or Without GoutDiabetic NephropathyNCT02327754Sanwa Kagaku Kenkyusho Co., Ltd.60
已完成
不适用
Study on effect of topiroxostat administration on serum creatinine level in patients with hyperuricemia.HyperuricemiaJPRN-UMIN000039120Koto Hospital104
已完成
不适用
Study on the influence of Topiroxostat on renal functiohyperuricemiaJPRN-UMIN000034118Sato Clinic59
已完成
4 期
Effect of febuxisostat on serum uric acid levels and endothelial function in patients with hyperuricemiaHyperuricemiaJPRN-UMIN000008753Department of Cardiovascular Medicine, Juntendo University School of Medicine10
进行中（未招募）
1 期
The effect of Ruboxistaurin on Clinically Significant Macular Edema in Patients with Diabetes Mellitus, as assessed by Optical Coherence TomographyDiabetic Macular Edema (DME), is the most common cause of visual impairment in patients with diabetic retinopathy (DR). It is the accumulation of extracellular fluid in the retinal tissues of the macula and is a microvascular complication of diabetes. In this study patients will have macular edema that meets the Early Treatment Diabetic Retinopathy Study (ETDRS) criteria for clinically significant macular edema (CSME), (but patients with imminently vision threatening macular edema are excluded).EUCTR2005-000900-15-GBEli Lilly and Company300