NCT06115382进行中（未招募）2 期
Sing for Your Saunter: Using Self-Generated Rhythmic Cues to Enhance Gait in Parkinson's
适应症
干预措施
试验速览
- 阶段
- 2 期
- 状态
- 进行中（未招募）
- 入组人数
- 74
- 试验地点
- 1
- 主要终点
- Gait speed
研究概览
简要总结
The goal of this clinical trial is to compare to rhythm-based walking interventions to enhance gait in people with Parkinson's disease. The main questions it aims to answer are:
- How does rhythm-based training influence walking performance?
- How does brain activity change following rhythm-based training? Participants will perform walking to music and walking while singing, and will train on the use of these rhythms for 12 weeks. The investigators will compare the effects of training with music to training with singing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •at least 30 years of age
- •diagnosis of idiopathic, typical Parkinson disease according to the UK Brain Bank Criteria
- •Hoehn & Yahr stages 2-3 (mild to moderate disease severity)
- •evidence of walking impairment (score at least 1 on gait item of MDS_UPDRS)
- •4) stable on all Parkinson disease medications for at least 2 months prior to study entry 5) willing and able to provide informed consent 6) right-handed
排除标准
- •diagnosis of any other neurological condition
- •a score of 2 or greater on item # 3 on the freezing of gait questionnaire
- •significant cognitive impairment
- •unstable medical or concomitant illnesses or psychiatric conditions which, in the opinion of the investigators, would preclude successful participation
- •cardiac problems that interfere with ability to safely participate
- •orthopedic problems in the lower extremities or spine that may limit walking
- •contraindications for magnetic resonance imaging
- •unable to walk for 10 continuous minutes independently
- •left-handed
- •uncontrolled tremor or dyskinesia
研究组 & 干预措施
External cueing
Experimental
External cueing using music, one hour sessions twice weekly for 12 weeks.
干预措施: External Cueing Training (Behavioral)
Self cueing
Experimental
Self-cueing training using singing, one hour sessions twice weekly for 12 weeks.
干预措施: Self Cueing Training (Behavioral)
结局指标
主要结局
Gait speed
时间窗: Baseline and 12 weeks
How quickly someone walks
MRI Bold Beta Weights
时间窗: Baseline and 12 weeks
Measure of blood oxygen levels in different brain regions indicative of level of activity within different brain regions
次要结局
未报告次要终点
研究者
Gammon M Earhart
Professor
Washington University School of Medicine
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Sing for Your Saunter - Dementia SupplementParkinson Disease DementiaParkinson DiseaseNCT04518917Washington University School of Medicine17
已完成
不适用
Sing for Your SaunterParkinson DiseaseNCT04246476Washington University School of Medicine67
已完成
不适用
Move to the Music - the effect of music cues on walking in people with 2 types of progressive neurological disorder.Progressive Supranuclear PalsyNeurological - Neurodegenerative diseasesPhysical Medicine / Rehabilitation - PhysiotherapyNeurological - Alzheimer's diseaseAlzheimer's DiseaseACTRN12616000851460a Trobe University20
已完成
2 期
Self-Managed Walking Improves FunctionDiabetes MellitusPeripheral Arterial DiseaseNCT00611988University of Kansas145
撤回
2 期
Rhythmic Auditory Stimulation and Walking Performance in Multiple Sclerosis (MS) PatientsGait Disturbance in Multiple Sclerosis PatientsNCT01086371The Cleveland Clinic