Long-term Follow-up of the Helsinki Businessmen Study Cohort of Men Born in 1919-1934
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 3,490
- 主要终点
- Total mortality: national registers
研究概览
简要总结
The Helsinki Businessmen Study (HBS) is a clinico-epidemiological longitudinal study started in 1964. It also included a 5-year randomized, controlled multifactorial primary prevention trial of cardiovascular diseases between 1974-1980. The cohort is being actively followed-up through national registers since the 1980, and since 2000 with regular questionnaire surveys. Latest in 2015. Also clinical and laboratory studies have been performed in random subcohorts. Follow-up is ongoing with new hypothesis-generating research questions.
详细描述
The Helsinki Businessmen Study (HBS) was originally a convenient cohort of male executives and businessmen (born 1919-1934, n=3490), who participated in health check-ups between 1964-1973, but since the beginning of 1970s it has developed into a clinico-epidemiological longitudinal study. Primary focus was on the prevention of cardiovascular diseases (CVD), but since 2000 focus has been shifting to geriatrics, and with its long follow-up (up to 50 years) HBS can be seen as a "life-course" study. Traditional CVD risk factors are available from the 1960s and in 1974 participants (available n=3310) were divided in groups according to their clinical status and CVD risk. Two high-risk groups (n=1222) and low-risk group (n=593) participated in a 5-year multifactorial primary prevention study in 1974-1980 (in-trial and post-trial results have been published in 1985 and 1991). The whole original cohort has been followed-up from national registers since 1985 and with regular questionnaire surveys since 2000. Random subcohorts have been studied clinically with laboratory and genetic examinations in 2003 and 2011. The latest questionnaire survey was performed in winter 2015 by which two thirds of the original cohort had died. Follow-up of the cohort is ongoing and new research questions formulated..
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 31 Years 至 46 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Participants of director studies at the Institute of Occupational Health in Helsinki, Finland, between 1964-1973
排除标准
- •Non-participants
结局指标
主要结局
Total mortality: national registers
时间窗: change from baseline up to 612 months
次要结局
- Health-related quality of life: questionnaire data(change from baseline up to 612 months)
- Geriatric syndromes and disability: questionnaires, clinical examinations, registers(change from baseline up to 612 months)
- Morbidity: self-report, national registers, hospital and autopsy records(change from baseline up to 612 months)
- Medications: self-report, national registers(change from baseline up to 612 months)
- Cause-specific mortality: national registers, autopsy records(change from baseline up to 612 months)
研究者
Timo Strandberg
Professor
Helsinki University Central Hospital