Impact of Aspergillus on Chronic Obstructive Pulmonary Disease Evolution
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 8
- 主要终点
- presence of aspergillus in sputum or respiratory samples
研究概览
简要总结
This is a prospective multicenter cohort study which includes all consecutive COPD patients who come for a visit in one the participating pneumologist. They will have to do a sputum and to complete some questionnaries. Questionnaries will be redone by phone after 1 and 3 months and during the visit after 6 months. We will correlate aspergillus presence in sputum with quality of life (QoL), and COPD symptoms evaluated by questionnaires.
详细描述
Aspergillosis disease is a growing problem. These diseases are not yet uncommon in chronic obstructive pulmonary disease patients. (COPD).
Aspergillosis disease are very difficult to be diagnosed or treated. Isolation of aspergillus in sputum of patients is not always responsible of a real disease. Need of treatment is discussed. That is why, we will conduct a prospective cohort study to evaluate aspergillus rate in respiratory samples of COPD patients (GOLD stage III or IV)
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •COPD patients GOLD stage III and IV
排除标准
- •Cystic fibrosis
- •Pulmonary fibrosis
- •hematological malignancy
- •known aspergilloma
- •allergic bronchopulmonary aspergillosis
结局指标
主要结局
presence of aspergillus in sputum or respiratory samples
时间窗: one year before inclusion
sputum examination
次要结局
- Dyspnea with MMRC score(day of inclusion)