NCT07718373尚未招募不适用
Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery: a Target Trial Emulation
Xijing Hospital0 个研究点目标入组 5,000 人开始时间: 2026年7月20日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 5,000
- 主要终点
- Acute kidney injury
研究概览
简要总结
Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial function. investigators emulated a target trial to evaluate whether early perioperative L-arginine was associated with a lower risk of AKI after cardiac surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •·adults admitted to the ICU after CPB-assisted cardiac surgery
排除标准
- •congenital heart disease,
- •surgery requiring deep hypothermic circulatory arrest,
- •a preoperative baseline estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m²,
- •AKI already present prior to ICU admission
研究组 & 干预措施
No L-arginine
No L-arginine therapy within 3 postoperative days
L-arginine
Initiation of L-arginine within 3 postoperative days
干预措施: L-arginine (Drug)
结局指标
主要结局
Acute kidney injury
时间窗: within 7 postoperative days
defined by KDIGO criteria
次要结局
- 7-day mortality.(7 day)
研究者
Chong Lei, MD & phD
Principal investigator, Head of Anesthesia Clinical Research Center, Xijing Hospital
Xijing Hospital
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