Pain Modulatory Profiles in Massage for Healthy Participants
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Change from baseline in Pressure Pain Threshold
研究概览
简要总结
One in ten adults experience widespread pain. Neck pain, for example, is a prevalent condition with a high rate of recurrence that affects between 10.4% and 21.3% of the population annually.
Massage is a common manual therapy intervention for individuals with musculoskeletal pain. However, the mechanisms of massage are not well established. Also, the conditioned pain modulation (CPM) paradigm is a dynamic quantitative sensory testing measure of a pain inhibitory process in which pain sensitivity is lessened in response to a remotely applied painful stimulus.
This study will evaluate the association between pain inducing massage and the conditioned pain modulation paradigm.
详细描述
Conditioned pain modulation (CPM) is the physical manifestation of the diffuse noxious inhibitory control (DNIC), an endogenous pain inhibitory pathway in which pain inhibits pain. Conditioned pain modulation is less efficient in individuals with chronic pain conditions and it is a predictor for the development of chronic pain.
Massage is a common manual therapy intervention for individuals with musculoskeletal pain. Greater changes in pain sensitivity occur following pain inducing massage suggesting a mechanism dependent upon the efficiency of the conditioned pain modulation response.
The study team will evaluate the association between pain inducing massage and the conditioned pain modulation paradigm. Healthy participants will be randomly assigned to receive a pain inducing massage, a pain free massage, or participate in a coldpressor task. Pre-and post intervention pain sensitivity including conditioned pain modulation will be assessed. The study team will determine if analgesia induced by massage is similar to the conditioned pain modulation paradigm and compare changes in pain sensitivity between groups.
Previous research has indicated pain inducing massage is more effective than pain free massage suggesting a mechanism dependent upon conditioned pain modulation. However, this study will be the first to systematically investigate if analgesia induced by pain inducing massage is similar to the conditioned pain modulation paradigm. Furthermore, this study will be the first to determine the association between baseline conditioned pain modulation and massage related hypoalgesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •pain free
- •blood pressure under 140/90 mmHg
- •ability of therapist to locate necessary trigger points on participant
排除标准
- •blood pressure over 140/90 mmHg
- •inability of therapist to locate necessary trigger points on participant
- •systemic medical condition known to affect sensation (i.e. diabetes)
- •regular use of prescription pain medication to manage pain
- •current or history of chronic pain condition
- •currently using blood thinning medication
- •any blood clotting disorder such as hemophilia
- •any contraindication to application of ice or cold pack, such as: uncontrolled hypertension, cold urticaria, cryoglobulinemia, paroxysmal cold hemoglobinuria, and circulatory compromise
- •non-English speaking
研究组 & 干预措施
Pain Inducing Massage
Participants will receive manual pressure applied to one myofascial trigger point.
干预措施: Pain Inducing Massage (Other)
Pain Free Massage
Participants will receive light touch applied to one myofascial trigger point.
干预措施: Pain Free Massage (Other)
Coldpressor
Participants will place hand into water cooled to 6 degrees Celsius (males) or 8 degrees Celsius (females).
干预措施: Coldpressor (Other)
结局指标
主要结局
Change from baseline in Pressure Pain Threshold
时间窗: 2 hours
Pressure in kilograms at which ascending pressure stimulus first changes from pressure to painful
次要结局
- Change from baseline in Thermal Pain Threshold and Tolerance(2 hours)
- Change from baseline in Pressure Pain Tolerance(2 hours)
- Change from baseline in Ramp and Hold(2 hours)
- Change from baseline in Temporal Summation(2 hours)
- Change from baseline in Conditioned Pain Modulation(2 hours)