The Role of Diffusion Magnetic Resonance Imaging (dMRI) in the Early Evaluation of Brain White Matter Diseases
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Sensitivity of diffusion magnetic resonance imaging
研究概览
简要总结
To assess the sensitivity and accuracy of diffusion magnetic resonance imaging (MRI), including diffusion-weighted imaging (DWI) metrics, in identifying early-stage changes in brain white matter related to various white matter diseases.
详细描述
Brain white matter diseases (WMDs) are a group of neurological conditions that involve changes to the brain's white matter, often leading to cognitive, motor, and sensory impairments.
Diffusion Magnetic Resonance Imaging (dMRI), has emerged as a powerful non-invasive imaging tool for evaluating microstructural changes in brain white matter. This protocol aims to investigate the role of dMRI in the early identification and characterization of brain white matter diseases, focusing on its potential for detecting abnormalities before the onset of overt clinical symptoms.
Diffusion-weighted imaging (DWI), one of the first advanced magnetic resonance imaging (MRI) techniques, has rapidly ascended on the basis of its applicability in strokes and some infectious diseases. Restricted diffusion is significant information in the context of vascular ischemia, helping to delimit the brain-damaged area
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18-80 years.
- •Clinical suspicion of early-stage white matter disease.
- •No prior diagnosis of significant neurological disorders (e.g., stroke, brain tumors).
- •Ability to provide informed consent.
排除标准
- •Pregnancy or breastfeeding.
- •Contraindications for magnetic resonance imaging (MRI) (e.g., metal implants, pacemakers).
- •Severe psychiatric or cognitive impairment that prevents participation.
- •Control Group: Healthy individuals without any clinical history of neurological diseases, matched by age and sex to the patient cohort.
结局指标
主要结局
Sensitivity of diffusion magnetic resonance imaging
时间窗: Immediately after diffusion magnetic resonance imaging (Up to 1 hour)
Sensitivity of diffusion magnetic resonance imaging to predict the early evaluation of brain white matter diseases
次要结局
未报告次要终点
研究者
Hekmat Samir Baumey
Lecturer of Diagnostic Radiology, Damnhour National Medical Institute
The General Authority for Teaching Hospitals and Institutes